Clinical studies investigating the use of leuprorelin in Asian women with endometriosis: a review

Osuga Y, Yutaka Osuga, Pao-Ling Torng, Pao‐Ling Torng, Jeng CJ, Cherng-Jye Jeng, Cherng‐Jye Jeng
Journal of obstetrics and gynaecology : the journal of the Institute of Obstetrics and Gynaecology · 2019 · vol. 39(3) , pp. 291–296 · doi:10.1080/01443615.2018.1460584 · PMID:30653368 · W2911082970
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This review of four Asian studies found that leuprorelin significantly improved endometriosis pain and quality of life but decreased hormone levels and bone density, with add-back therapy mitigating hormone reduction.

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Abstract

We aimed to examine how leuprorelin has been studied for the treatment of women with endometriosis in Asia. We conducted a literature search of PubMed, the Cochrane Library and ClinicalTrials.gov. This review includes randomised trials of women with endometriosis treated with leuprorelin in Asia. Phase I-IV clinical trials published between January 1 2000 and December 31 2016 and written in English were included. Four studies were identified, showing that leuprorelin significantly improves pain and quality of life. The oestrone and oestradiol levels are decreased by leuprorelin but can be increased using an 'add-back' therapy with conjugated equine oestrogen and methoxyprogesterone. Menopause is more common in women treated with leuprorelin. The bone mineral density is reduced in women treated with leuprorelin. There are limited studies investigating the use of leuprorelin for the treatment of endometriosis in Asian populations. However, the research that has been conducted supports the use of leuprorelin in an Asian population.

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Condition tags

endometriosis

MeSH descriptors

Endometriosis Leuprolide Asian People Asian People Endometriosis Endometriosis Female Female Gonadotropins Gonadotropins Gonadotropins Humans Humans Leuprolide Leuprolide Pain Pain Pain

Citation neighborhood (2-hop)

Papers in the corpus that this work cites (lower rings, blue) and that cite this one (upper rings, green). Dot size scales with the paper's in-corpus citation count — bigger dot = more influential within the endo/adeno field. Click a dot to open that paper. Outer rings show 2-hop neighbours — papers reached through the immediate citers/citees. [ collapse to 1-hop ]

References (27)

Cited by (1)

SciLite annotations

chemicals 12
goserelin goserelin goserelin goserelin estrone estradiol goserelin estrogen medroxyprogesterone goserelin mineral goserelin
organisms 2
noordeloos 2009062 noordeloos 2009062

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