Endometriose und Angiogenese

P. Kressin, K. Diedrich, Eduard Malik
In: Der Gynäkologe · 2002 · vol. 35(3) , pp. 224–231 · doi:10.1007/s00129-002-1162-z · W1485452542
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This review presents and summarizes angiogenesis mechanisms and related growth factors, finding that VEGF, angiopoietins, and matrix metalloproteinases are key to endometriosis development.

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Zusammenfassung Eine Reihe von Befunden unterstreicht die Bedeutung der Angiogenese für die Pathogenese der Endometriose. Die Angiogenese und deren relevante Faktoren werden in einer Übersicht dargestellt und bezüglich ihres Stellenwertes beurteilt. Der “vascular endothelial growth factor” (VEGF), die Angiopoietine 1 und 2, sowie verschiedene Matrixmetalloproteinasen werden im eutopen und ektopen Endometrium exprimiert. Aktuelle Ergebnisse zeigen, dass diese Faktoren Schlüsselpositionen in der Angiogenese der Endometriose einnehmen. So kann das bestehende Modell zur Transplantationstheorie um diese Faktoren ergänzt werden. Gleichzeitig ergeben sich neue Ansatzpunkte für zukünftige Therapiestrategien der Endometriose. Abstract Angiogenesis is a major step in the establishment of endometriosis. The mechanisms of angiogenesis and the related growth factors are presented and summarized to a model of angiogenesis in endometriosis. The Vascular endothelial growth factor (VEGF), the angiopoietins 1 and 2 as well as different matrixmetalloproteinases are expressed in the endometrium and endometriosis. Current results show that these factors take key positions in the angiogenesis of endometriosis. The existing model can be supplemented with these factors for the theory of retrograde menstruation. New starting-points arise for future therapy strategies of endometriosis at the same time. Similar content being viewed by others Author information Authors and Affiliations Rights and permissions About this article Cite this article Kressin, P., Diedrich, K. & Malik, E. Endometriose und Angiogenese. Gynäkologe 35, 224–231 (2002). https://doi.org/10.1007/s00129-002-1162-z Published: Issue date: DOI: https://doi.org/10.1007/s00129-002-1162-z

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