Effects of dienogest (a synthetic steroid) on coagulation, fibrinolysis, and platelet aggregation in female monkeys

Yukio Katsuki, Y Katsuki, Hidefumi Nobukata, H Nobukata, Tsutomu Ishikawa, T Ishikawa, Yoshimasa Hamada, Y Hamada, M Sato, Masami Sato, Y Shibutani
Toxicology letters · 1998 · vol. 98(1-2) , pp. 105–113 · doi:10.1016/s0378-4274(98)00109-x · PMID:9776567 · W1973584641
Lab / animal OA: closed CC0 ⤵ 2 in-corpus citations
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This study investigated the impact of dienogest on coagulation, fibrinolysis, and platelet aggregation in female monkeys, reporting its observed effects on these hemostatic parameters.

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Abstract

We investigated the effects of dienogest (0.1-10 mg/kg per day, p.o.) on coagulation, fibrinolysis and platelet aggregation in female rhesus monkeys. Then, we also examined those of medroxyprogesterone acetate (MPA, 10 mg/kg per day, p.o.) or danazol (10-1000 mg/kg per day, p.o.) on these parameters in the same species. In addition, we assessed the effects of dienogest (1 and 3 mg/kg per day, p.o.) or MPA (10 mg/kg per day, p.o.) on platelet aggregation and platelet lipids in female cynomolgus monkeys. At doses of 0.3 mg/kg or greater, dienogest increased the levels of several coagulation and anticoagulation factors, but had no effect on the prothrombin time, activated partial thromboplastin time, fibrinolysis, or platelet aggregation. MPA (10 mg/kg) had no effect on coagulation or fibrinolysis, but significantly potentiated platelet aggregation in response to ADP and collagen and also increased the platelet cholesterol-to-phospholipid ratio. Danazol (10 mg/kg or more) increased the activities of coagulation factors V, VII, VIII, X, XI, and XII in comparison to dienogest and MPA. Consequently, dienogest caused less potentiation of platelet aggregation than MPA and less potentiation of coagulation than danazol.

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MeSH descriptors

Blood Coagulation Fibrinolysis Hormone Antagonists Medroxyprogesterone Acetate Nandrolone Platelet Aggregation Animals Blood Coagulation Blood Platelets Blood Platelets Blood Platelets Cholesterol Cholesterol Danazol Danazol Female Fibrinolysis Hormone Antagonists Macaca fascicularis Macaca mulatta

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