Y Hamada — Endo Lab

lab-animal 2000

Growth-stimulating effect of dienogest, a synthetic steroid, on rodent, canine, and primate mammary glands

Toxicology ·doi:10.1016/s0300-483x(00)00318-8

We observed hyperplasia of the mammary gland in female beagle dogs, but not in female rats and monkeys, in 91-day toxicity studies on dienogest. In order to elucidate a possible mechanism for its development and to account for this species …

lab-animal 1998

Effects of dienogest (a synthetic steroid) on coagulation, fibrinolysis, and platelet aggregation in female monkeys

Toxicology letters ·doi:10.1016/s0378-4274(98)00109-x

We investigated the effects of dienogest (0.1-10 mg/kg per day, p.o.) on coagulation, fibrinolysis and platelet aggregation in female rhesus monkeys. Then, we also examined those of medroxyprogesterone acetate (MPA, 10 mg/kg per day, p.o.) …

1982

360. Electronmicroscopic Study of Endometriosis Interna (Adenomyosis) : With Particular Reference to Proliferative Phase of Endometrium and Endometrial Cancer

lab-animal 1978

Investigation of mammalian ovulation with an in vitro perfused rabbit ovary preparation

American journal of obstetrics and gynecology ·doi:10.1016/s0002-9378(78)80007-6

An in vitro perfused rabbit ovary preparation has been developed to study local factors responsible for the ovulatory process. This preparation enables: (1) isolation of the ovary from systemic influences, (2) direct serial observations of …

lab-animal 1978

In vitro reversal of indomethacin-blocked ovulation by prostaglandin F2alpha

Fertility and sterility ·doi:10.1016/s0015-0282(16)43700-3

An in vitro perfused ovary preparation was used to study the role of prostaglandin F2alpha (PGF2alpha) in follicle rupture. The administration of PGF2alpha alone has been shown to restore indomethacin-blocked ovulation in rabbits and monkey…