Mortality risk associated with endometriosis: a systematic review and meta-analysis
Systematic review / meta-analysis
OA: closed
public-domain-us
AI-generated summary
This meta-analysis found no significant increase in all-cause mortality or mortality from specific diseases among women with endometriosis compared to the general population.
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Abstract
INTRODUCTION: Endometriosis is a chronic, estrogen-dependent gynecological disorder affecting approximately 10% of women worldwide that can cause pelvic pain, lead to infertility, and impair quality of life. Whether the condition elevates risk of mortality remains controversial. This systematic literature review and meta-analysis investigated the long-term survival of women with endometriosis.
METHOD: Studies reporting mortality among women with endometriosis were identified through PubMed, EMBASE, Web of Science, Scopus, and OpenGrey in accordance with PRISMA recommendations. Pooled data on all-cause mortality and mortality for specific diseases were meta-analyzed using a random-effects model. Heterogeneity was evaluated using the I2 statistic.
RESULTS: Women with endometriosis were not at significantly higher risk than the general population of women for mortality related to gynecological cancer (HR 1.56, 95% CI 0.72-3.39), non-cancerous cardiocerebral disease (HR 0.80, 95% CI 0.53-1.23), non-cancerous respiratory disease (HR 0.89, 95% CI 0.20-4.02), accidents/suicide (HR 1.33, 95% CI 0.99-1.79) or all causes combined (HR 1.00, 95% CI 0.82-1.21).
CONCLUSION: Endometriosis does not appear to increase risk of all-cause mortality or mortality due to specific diseases. Future research should focus on how interventions or management influence other long-term outcomes, such as quality of life and mental and reproductive health.
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Papers in the corpus that this work cites (lower rings, blue) and that cite this one (upper rings, green). Dot size scales with the paper's in-corpus citation count — bigger dot = more influential within the endo/adeno field. Click a dot to open that paper. Outer rings show 2-hop neighbours — papers reached through the immediate citers/citees. [ collapse to 1-hop ]
References (35)
- A prospective study of endometriosis and risk of benign breast disease via openalex
- Cancer Implications for Patients with Endometriosis via openalex
- Does endometriosis increase the risks of endometrial hyperplasia and endometrial cancer? via openalex
- Endometriosis and long-term cardiovascular risk: a nationwide Danish study via openalex
- Endometriosis and Risk of Coronary Heart Disease via openalex
- Endometriosis and uterine fibroids and risk of premature mortality: prospective cohort study via openalex
- Endometriosis: A Review via openalex
- Endometriosis as a Risk Factor for Ischemic and Hemorrhagic Stroke: A Population-Based Cohort Study via openalex
- Endometriosis: cost estimates and methodological perspective via openalex
- Endometriosis: pathogenesis and treatment via openalex
- Epigenetic Dysregulation in Endometriosis: Implications for Pathophysiology and Therapeutics via openalex
- Global, Regional and National Burden of Infertility due to Endometriosis: Results From the Global Burden of Disease Study 2021 and Forecast to 2044 via openalex
- Increased risk of cardiovascular disease in women with endometriosis: A systematic review and meta-analysis via openalex
- Mortality of midlife women with surgically verified endometriosis-a cohort study including 2.5 million person-years of observation via openalex
- Risk of cardiovascular outcomes among women with endometriosis in the United Kingdom: a retrospective matched cohort study via openalex
- Risk of major adverse cardiovascular and cerebrovascular events in Taiwanese women with endometriosis via openalex
- The social and psychological impact of endometriosis on women's lives: a critical narrative review via openalex
- W1979423827 via openalex
- W4416775191 via openalex
- W2088095316 via openalex
- W2580880983 via openalex
- W2900338021 via openalex
- W3039422431 via openalex
- W3134885188 via openalex
- W4211081176 via openalex
- W4281637918 via openalex
- W4384564648 via openalex
- W4386648226 via openalex
- W4389060157 via openalex
- W4391850571 via openalex
- W4403193537 via openalex
- W4405222978 via openalex
- W4408361704 via openalex
- W4409702302 via openalex
- W4412524283 via openalex
Source provenance
- europepmc
- last seen: 2026-10-12T06:17:10.165071+00:00
- openalex
- last seen: 2026-08-08T06:02:04.998724+00:00
- pubmed
- last seen: 2026-10-12T06:10:48.426987+00:00
- unpaywall
- last seen: 2026-05-15T02:00:00.661756+00:00
License: public-domain-us
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Courtesy of the U.S. National Library of Medicine
Courtesy of the U.S. National Library of Medicine