GnRH analogueによる子宮内膜症治療における結合型エストロゲンを用いたadd-back療法の検討
This study investigated the effect of conjugated estrogen add-back therapy with GnRH analogue treatment for endometriosis by comparing bone mineral density and osteocalcin levels between two groups of patients.
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本研究は、GnRHアナログ治療に伴う低エストロゲン状態による副作用を軽減する目的で、結合型エストロゲンを用いたadd-back療法が骨塩量に与える影響を子宮内膜症28例で比較した。酢酸リュープロレリン3.75mgを4週に1回投与する群(13例)と、同時に結合型エストロゲン0.625mgを連日経口投与する群(15例)に分け、DXA法で治療前後の腰椎(L2-4)骨塩量と血中オステオカルシンを評価した結果、いずれも骨塩量は低下したが、減少率は単独群5.5%に対しadd-back群1.6%で、骨塩量低下が有意に小さかった。また、オステオカルシンは単独群で有意に上昇したのに対しadd-back群では有意な変化がなく、一般臨床症状と低エストロゲン由来の血管運動症状はいずれの群でも改善し、血管運動症状はadd-back群でより軽減された。This paper is centrally about endometriosis — GnRHアナログ治療に対する結合型エストロゲンadd-back療法の骨塩量および症状への影響を検討している。
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