Long-Term Use of the Low Dose LHRH Analogue Combined With Monthly Medroxy-Progesterone Administration

A. Lemay, Lemay A, Dodin Dewailly, Dodin Dewailly S, S Dodin Dewailly
Hormone research · 1989 · vol. 32(1) , pp. 141–145 · doi:10.1159/000181330 · PMID:2515146 · W2036430860
article OA: closed CC0 ⤵ 5 in-corpus citations
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⚙ AI-generated summary by gemini-2.5-flash-lite, 2026-06-07 ⓘ

Low-dose buserelin and monthly medroxy-progesterone effectively treated endometriosis-related pelvic pain and uterine bleeding with few side effects, though minor bone demineralization may occur.

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Abstract

In a pilot study, chronic pelvic pain associated with endometriosis, dysmenorrhoea or menorrhagia has been treated for prolonged periods with low dose buserelin (daily) and medroxy-progesterone (monthly). The partial inhibition of ovarian function was effective in relieving pain and controlling uterine bleeding, with few side effects. There was no change in serum cholesterol level. A possible small bone demineralisation effect has been observed.

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Condition tags

dysmenorrheaendometriosischronic_pelvic_pain

MeSH descriptors

Buserelin Dysmenorrhea Endometriosis Medroxyprogesterone Menorrhagia Adult Buserelin Buserelin Drug Therapy, Combination Dysmenorrhea Endometriosis Female Humans Medroxyprogesterone Medroxyprogesterone Menorrhagia

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europepmc
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License: CC0 · commercial use OK