Comparison between mefenamic acid and danazol in the treatment of established menorrhagia
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⤵ 35 in-corpus citations
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This study found danazol significantly reduced menstrual blood loss more than mefenamic acid, but with more adverse side-effects.
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Abstract
Forty women with established menorrhagia were treated with either mefenamic acid (500 mg thrice daily for 3-5 days in two cycles) or danazol (100 mg twice daily for 60 days) in an open parallel group randomized study. Mefenamic acid reduced mean menstrual blood loss from 160 ml to 127 ml (20%, P less than 0.01). Danazol reduced mean menstrual loss from 163 ml to 65 ml (60%, P less than 0.001). The percentage reduction in menstrual blood loss was significantly greater in the danazol group than in the mefenamic acid group, but the adverse side-effects occurred significantly more often in the danazol group (75%) than in the mefenamic acid group (30%, P less than 0.005). Overall, approximately half the women in each group were prepared to continue with the treatment they received to reduce their menstrual bleeding.
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References (14)
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Cited by (28)
- Danazol 2022
- Variation of outcome reporting in studies of interventions for heavy menstrual bleeding: a systematic review 2022
- Non-steroidal anti-inflammatory drugs for heavy menstrual bleeding 2019
- Medical management of heavy menstrual bleeding: a comprehensive review of the literature 2015
- Non-steroidal anti-inflammatory drugs for heavy menstrual bleeding 2013
- Management of menorrhagia associated with chemotherapy-induced thrombocytopenia in women with hematologic malignancy 2011
- Efficacy of vaginal danazol treatment in women with menorrhagia during fertile age 2008
- Medical therapies for chronic menorrhagia 2007
- Nonsteroidal anti-inflammatory drugs for heavy menstrual bleeding 2007
- Danazol 2007
- Medical management of menorrhagia 2005
- Benefits and risks of pharmacological agents used for the treatment of menorrhagia 2004
- Abnormal uterine bleeding: medical treatment with vaginal danazol and five-year follow-up 2004
- Medical management of dysfunctional uterine bleeding 2003
- Danazol for heavy menstrual bleeding 2002
- Medical management of dysfunctional uterine bleeding 1999
- A double-blind randomised study comparing danazol and medroxyprogesterone acetate in the management of menorrhagia 1998
- Dysfunctional uterine bleeding 1998
- Nonsteroidal anti-inflammatory drugs for heavy menstrual bleeding 1998
- A randomised comparison of medical and hysteroscopic management in women consulting a gynaecologist for treatment of heavy menstrual loss 1997
- Menorrhagia: a clinical update 1996
- Managing menorrhagia 1995
- Assessment of medical treatments for menorrhagia 1994
- A comparative study of danazol, a regimen of decreasing doses of danazol, and norethindrone in the treatment of objectively proven unexplained menorrhagia 1993
- Abnormal uterine bleeding. Finding and treating the cause 1993
- Danazol in the Treatment of Menorrhagia: The Effect of a 1 Month Induction Dose (200 mg) and 2 Month's Maintenance Therapy (200 mg, 100 mg, 50 mg or placebo) 1992
- Medical management of menorrhagia 1992
- Randomized trial of 2 hormonal and 2 prostaglandin-inhibiting agents in women with a complaint of menorrhagia 1991
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- openalex
- last seen: 2026-06-10T17:14:06.276822+00:00
- pubmed
- last seen: 2026-10-08T21:18:35.845501+00:00
- unpaywall
- last seen: 2026-10-11T06:28:45.473802+00:00
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