The effect of danazol on tumour control and weight loss in patients on tamoxifen therapy for advanced breast cancer: a randomised double-blind placebo controlled trial

James F. Bishop, J F Bishop, J G Smith, Jennifer Smith, Peter Jeal, P N Jeal, Robin Murray, R Murray, Roslyn Drummond, R M Drummond, Paula Pitt, P Pitt, I N Olver, Ian Olver, A K Bhowal, Ankur Bhowal
European journal of cancer (Oxford, England : 1990) · 1993 · vol. 29(6) , pp. 814–818 · doi:10.1016/s0959-8049(05)80415-0 · PMID:8484970 · W1972656449
RCT OA: closed CC0
View on OpenAlex View on PubMed View at publisher
⚙ AI-generated summary by gemini-2.5-flash-lite, 2026-06-07 ⓘ

This randomized double-blind placebo-controlled trial investigated the effects of danazol on tumor control and weight loss in advanced breast cancer patients receiving tamoxifen therapy.

One-sentence paraphrase of the abstract; not a substitute for reading it. No clinical advice. How this works

Abstract

To assess the effect of danazol in advanced breast cancer 183 patients were randomised to receive either tamoxifen plus danazol or tamoxifen plus placebo. Patients underwent systemic work-up pretreatment then every 12 weeks or sooner if they clinically progressed. There were no differences in objective response rates with tamoxifen plus danazol vs. tamoxifen plus placebo (27% vs. 24%), time to progression (median 6.4 vs. 6.2 months) or survival (median 22.6 vs. 23.5 months) when the two arms were compared (all P > 0.5). The addition of danazol to tamoxifen had no effect on time to progression when adjusted for significant prognostic factors in a multivariate analysis. However, it was found incidentally that weight was stable on tamoxifen plus danazol (average gain 0.6 kg, S.E. 0.6 kg) compared with a significant loss on tamoxifen plus placebo (average loss 2.0 kg, S.E. 0.6 kg, P = 0.003). The average weight was maintained on tamoxifen plus danazol even in patients who did not respond to treatment.

My notes (saved in your browser only)

MeSH descriptors

Antineoplastic Combined Chemotherapy Protocols Breast Neoplasms Weight Loss Antineoplastic Combined Chemotherapy Protocols Breast Neoplasms Breast Neoplasms Danazol Danazol Double-Blind Method Female Humans Middle Aged Placebos Prognosis Receptors, Estrogen Receptors, Estrogen Tamoxifen Tamoxifen Weight Loss

Citation neighborhood (2-hop)

Papers in the corpus that this work cites (lower rings, blue) and that cite this one (upper rings, green). Dot size scales with the paper's in-corpus citation count — bigger dot = more influential within the endo/adeno field. Click a dot to open that paper. Outer rings show 2-hop neighbours — papers reached through the immediate citers/citees. [ collapse to 1-hop ]

References (27)

SciLite annotations

chemicals 12
danazol tamoxifen danazol tamoxifen danazol tamoxifen tamoxifen danazol tamoxifen danazol tamoxifen danazol

Source provenance

openalex
last seen: 2026-05-11T06:42:59.773506+00:00
pubmed
last seen: 2026-10-08T21:59:37.277143+00:00
scilite
last seen: 2026-05-18T04:26:01.642840+00:00
unpaywall
last seen: 2026-10-18T06:28:46.490043+00:00
License: CC0 · commercial use OK