The impact of long-term gonadotropin-releasing hormone analogue treatment on preclinical abortions in patients with severe endometriosis undergoing in vitro fertilization-embryo transfer

D Dicker, Dicker D, Dov Dicker, Goldman JA, J A Goldman, Jack A. Goldman, T Levy, Levy T, Tally Levy, D Feldberg, Feldberg D, Dov Feldberg, Jacob Ashkenazi, J Ashkenazi, Ashkenazi J
Fertility and sterility · 1992 · vol. 57(3) , pp. 597–600 · doi:10.1016/s0015-0282(16)54906-1 · PMID:1740204 · W2404983744
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This study investigated the effect of long-term GnRH analogue treatment on preclinical abortions in severe endometriosis patients undergoing IVF-ET.

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Abstract

OBJECTIVE: To examine the relationship between endometriosis and preclinical abortions and to evaluate the effect of gonadotropin-releasing hormone analogue (GnRH-a) therapy on these pregnancies. DESIGN AND PATIENTS: Of 67 women with severe endometriosis referred to us for in vitro fertilization-embryo transfer (IVF-ET), 32 underwent ovarian stimulation for oocyte retrieval with menotropins (protocol A), whereas the other 35 were admitted for the procedure after a 6-month period of hormonal suppression with a GnRH agonist (protocol B). The clinical impact of the preclinical and clinical pregnancies in both treatment protocols were evaluated on the basis of oocyte classification and embryo quality score. SETTING: All patients were treated in our IVF Unit. MAIN OUTCOME MEASURE: Clinical pregnancy was used as our main outcome measure of success. RESULTS: A significantly higher number of preclinical pregnancies (P less than 0.0001) occurred in patients treated by protocol A. After GnRH-a treatment, the preclinical pregnancy rate declined significantly (P less than 0.0001), whereas the clinical pregnancy rate per cycle and per transfer rose significantly (P less than 0.0001 and P less than 0.0001, respectively). Furthermore, clinical pregnancies had a significantly better mean embryo quality score in comparison with preclinical pregnancies (P less than 0.0001). CONCLUSIONS: It is concluded that combining GnRH-a therapy before IVF-ET provides an improved treatment modality for preclinical abortions and infertility associated with severe endometriosis.

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Condition tags

endometriosis

MeSH descriptors

Abortion, Spontaneous Abortion, Spontaneous Embryo Transfer Embryo Transfer Endometriosis Fertilization in Vitro Fertilization in Vitro Gonadotropin-Releasing Hormone Pregnancy Complications Triptorelin Pamoate Triptorelin Pamoate Triptorelin Pamoate Adult Adult Delayed-Action Preparations Delayed-Action Preparations Endometriosis Endometriosis Endometriosis Female

Citation neighborhood (2-hop)

Papers in the corpus that this work cites (lower rings, blue) and that cite this one (upper rings, green). Dot size scales with the paper's in-corpus citation count — bigger dot = more influential within the endo/adeno field. Click a dot to open that paper. Outer rings show 2-hop neighbours — papers reached through the immediate citers/citees. [ collapse to 1-hop ]

References (20)

Cited by (50)

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