Efficacy Of Gonadotropin‐Releasing Hormone Agonist (Buserelin) in The Treatment Of Endometriosis

L Rönnberg, Rönnberg L, Lars Rönnberg, A Koskimies, Koskimies A, Aarne I. Koskimies, Laatikainen T, Timo Laatikainen, T Laatikainen, T Ranta, Ranta T, TAPIO RANTA, Saastamoinen J, J Saastamoinen
Acta obstetricia et gynecologica Scandinavica · 1989 · vol. 68(1) , pp. 49–53 · doi:10.3109/00016348909087689 · PMID:2508418 · W2123399607
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Buserelin treatment for 6 months reduced endometriosis scores by 82.2%, resolved associated symptoms, and resulted in pregnancy in over half of desiring patients with minimal side effects.

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Abstract

In a multicenter study, the efficacy of and tolerance of 6 months' intranasal gonadotropin-releasing hormone agonist (buserelin) treatment (300 micrograms x 3/day) on laparoscopically verified endometriosis was evaluated in 25 patients. At second-look laparoscopy at the end of medication, the mean endometriosis score had fallen by 82.2%. All endometriosis-associated symptoms and physical findings decreased or almost disappeared during buserelin administration. After discontinuing therapy, they showed a tendency to reappear, but nevertheless they were milder after one year of follow-up, than before treatment. Seven (54%) of the 13 women wishing pregnancy actually conceived. Vaginal irregular spotting bleedings during the first 2 months occurred in 7 patients. No patient withdrew from the trial because of side effects, although almost all women developed symptoms of estrogen deficiency (serum estradiol concentrations fell to menopausal levels).

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Condition tags

endometriosis

MeSH descriptors

Buserelin Endometriosis Pregnancy Administration, Intranasal Adult Buserelin Buserelin Clinical Trials as Topic Endometriosis Endometriosis Endometriosis Female Follow-Up Studies Hormones Hormones Humans Multicenter Studies as Topic

Citation neighborhood (2-hop)

Papers in the corpus that this work cites (lower rings, blue) and that cite this one (upper rings, green). Dot size scales with the paper's in-corpus citation count — bigger dot = more influential within the endo/adeno field. Click a dot to open that paper. Outer rings show 2-hop neighbours — papers reached through the immediate citers/citees. [ collapse to 1-hop ]

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