Future directions in endometriosis treatment: discovery and development of novel inhibitors of estrogen biosynthesis

Fabio Barra, Andrea Romano, Giovanni Grandi, Grandi G, Facchinetti F, Fabio Facchinetti, Simone Ferrero
Expert opinion on investigational drugs · 2019 · vol. 28(6) , pp. 501–504 · doi:10.1080/13543784.2019.1618269 · PMID:31072144 · W2944325431
Other OA: green CC0 ⤵ 9 in-corpus citations
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⚙ AI-generated summary by gemini-2.5-flash-lite, 2026-06-07 ⓘ

This paper explores novel inhibitors of estrogen biosynthesis enzymes, specifically AKR1C3, steroid sulphatase, 17β-HSD1, and aromatase, for future endometriosis treatment strategies.

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Abstract

KEYWORDS: Endometriosisestrogen biosynthesisAKR1C3steroid sulphatase17β-hydroxysteroid dehydrogenase 1aromatase inhibitors

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Condition tags

endometriosis

MeSH descriptors

Endometriosis Enzyme Inhibitors Estrogens Animals Animals Aromatase Inhibitors Aromatase Inhibitors Aromatase Inhibitors Drug Development Drug Development Drug Development Drug Discovery Drug Discovery Drug Discovery Endometriosis Endometriosis Endometriosis Enzyme Inhibitors Enzyme Inhibitors Estrogens

Citation neighborhood (2-hop)

Papers in the corpus that this work cites (lower rings, blue) and that cite this one (upper rings, green). Dot size scales with the paper's in-corpus citation count — bigger dot = more influential within the endo/adeno field. Click a dot to open that paper. Outer rings show 2-hop neighbours — papers reached through the immediate citers/citees. [ collapse to 1-hop ]

References (25)

Cited by (9)

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