Anaprox in dysmenorrhea: reduction of pain and intrauterine pressure
Non-randomised trial
OA: closed
CC0
⤵ 7 in-corpus citations
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This paper investigated the effects of Anaprox on dysmenorrhea, finding that it effectively reduced both pain and intrauterine pressure.
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Abstract
In a double-blind parallel trial, 24 dysmenorrheic women received a single dose of Anaprox (1,100 mg) or placebo. Over the next 2 hours, pain intensity was scored and intrauterine pressure was measured using an immobilized microballoon. At the end of 2 hours, all 11 patients given Anaprox (but only three of the 13 given placebo) experienced complete pain relief (p = 0.0004). The resting intrauterine pressure (IUP) decreased from a mean of 51.4 to 26.8 mm Hg in the Anaprox-treated group, while in the placebo group the mean resting IUP values remained essentially unchanged ( drop from 55.4 to 51.9 mm Hg was observed). This difference between the two treatment groups was statistically significant in favor of Anaprox (p = 0.03). Several patients from each group were given 0.2 mg of ergonovine by intramuscular injection following the 2 hour trial. In both groups, the resting IUP increased within 30 minutes; the corresponding increase in pain intensity was more pronounced, however, in the placebo group. These results support the premise that a decrease in resting IUP is directly linked to the pain-relieving effects of Anaprox.
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References (13)
- Endogenous levels of prostaglandin F2alpha and its main metabolites in plasma and endometrium of normal and dysmenorrheic women via openalex
- The effect of naproxen-sodium on the intrauterine pressure and menstrual pain of dysmenorrheic patients via openalex
- The effect of naproxen-sodium on the prostaglandin concentrations of the menstrual blood and uterine "jet-washings" in dysmenorrheic women via openalex
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- W2406115823 via openalex
- W2418173018 via openalex
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- W1640985513 via openalex
Cited by (7)
- Prostaglandins, prostaglandin inhibitors and their roles in gynaecological disorders 1992
- Eicosanoids, menstruation and menstrual disorders 1987
- Distribution analysis of intrauterine pressure in nonpregnant dysmenorrheic women 1984
- Prostaglandin synthetase inhibitors in the treatment of primary dysmenorrhea. Outcome trials reviewed 1984
- Prostaglandins and nonsteroidal antiinflammatory drugs in dysmenorrhea 1983
- Naproxen sodium, aspirin, and placebo in primary dysmenorrhea. Reduction of pain and blood levels of prostaglandin F2-alpha metabolite 1981
- Naproxen and naproxen sodium in dysmenorrhea: development from in vitro inhibition of prostaglandin synthesis to suppression of uterine contractions in women and demonstration of clinical efficacy 1979
SciLite annotations
chemicals 1
ergonovine
Source provenance
- openalex
- last seen: 2026-06-10T17:14:06.276822+00:00
- pubmed
- last seen: 2026-10-08T21:57:33.264577+00:00
- scilite
- last seen: 2026-05-18T04:57:49.680383+00:00
- unpaywall
- last seen: 2026-10-16T06:24:35.758740+00:00
License: CC0
· commercial use OK