Analysis of factors affecting pregnancy outcomes in patients with adenomyosis after high intensity focused ultrasound ablation: a retrospective study

Ma R, Rong Ma, Briones DAB, Diego Armando Burgos Briones, Zou M, Min Zou, Xiong Y, Yu Xiong, Bai J, Jin Bai, Zhang L, Lian Zhang
In: Authorea Inc. · 2024 · doi:10.22541/au.170992512.28849174/v1 · W4392602500
Observational preprint OA: gold CC0 ⤵ 1 in-corpus citation
📄 Open PDF View on OpenAlex View at publisher
⚙ AI-generated summary by gemini-2.5-flash-lite, 2026-06-06 ⓘ

This retrospective study found that high-intensity focused ultrasound (HIFU) positively impacts fertility in adenomyosis patients, with pelvic adhesion, infertility history, and lesion volume affecting pregnancy outcomes.

One-sentence paraphrase of the abstract; not a substitute for reading it. No clinical advice. How this works

Abstract

Objectives: To analyze the factors influencing pregnancy outcomes in patients with adenomyosis after high intensity focused ultrasound (HIFU) treatment. Design: A retrospective study. Setting: Department of Gynaecology in a single centre in China. Population: Patients with adenomyosis under the age of 45 years who had a desire for future fertility. Methods: Pregnancy outcomes and factors influencing pregnancy outcomes were analyzed using multivariate regression analysis and survival analysis Main Outcome Measures: The improvement of symptoms and reproductive related information were recorded during the average follow-up time of 73.8 ± 28.6 months. Results: After HIFU, 100 of 231 (43.3%) patients became pregnant within 96 months. Among them, 77 conceived naturally, and 23 patients conceived by in vitro fertilization and embryo transfer (IVF-ET). In the 108 infertile patients, 31 (28.7%) became pregnant. At the end of follow-up, 70 successfully delivered 71 healthy babies. No uterine rupture occurred during pregnancy and delivery. The cumulative pregnancy rate increased faster in the IVF-ET group than that in the natural pregnancy group. Patients with pelvic adhesion and infertility history had lower pregnancy possibility than patients without pelvic adhesion and infertility history (OR<1, P<0.05). Patients with small adenomyotic lesion volume had a greater possibility of pregnancy than that of patients with large lesion volume (OR < 1, P < 0.05). Conclusions: HIFU has a positive effect on fertility, and IVF-ET seems to have improved the pregnancy rate of the patients with adenomyosis treated with HIFU. Pelvic adhesion, infertility history, and adenomyotic lesion volume were factors affecting pregnancy.

My notes (saved in your browser only)

Condition tags

adenomyosisinfertility

Citation neighborhood (2-hop)

Papers in the corpus that this work cites (lower rings, blue) and that cite this one (upper rings, green). Dot size scales with the paper's in-corpus citation count — bigger dot = more influential within the endo/adeno field. Click a dot to open that paper. Outer rings show 2-hop neighbours — papers reached through the immediate citers/citees. [ collapse to 1-hop ]

References (30)

Cited by (1)

Source provenance

europepmc
last seen: 2026-10-19T06:33:03.970010+00:00
openalex
last seen: 2026-06-10T17:14:06.276822+00:00
License: CC0 · commercial use OK