Scanning electron microscopic and immunohistochemical studies of pelvic endometriosis
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Scanning electron and immunohistochemical studies of pelvic endometriosis suggest metaplasia from the pelvic peritoneum, observing similar cellular and immunoreactive characteristics between endometriotic glands and normal endometrial glands.
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Abstract
The pathogenesis of pelvic endometriosis has been studied by using scanning electron and light microscopy, observing the surface structure of bluish lesions obtained from 26 patients during laparotomy. Paraffin sections included another 17 tissue samples of endometriosis, based on immunohistochemical responses to epithelial membrane antigen, keratin and vimentin. Ultrastructurally, the surface epithelial cells could not be detected in 13 out of 17 pelvic peritoneal endometriosis samples. In one case in which the surface peritoneal cells were seen histologically to dip into the subperitoneal stroma, many surface peritoneal infoldings were observed, and ciliated cells were detected at the edge of these infoldings. Ovarian endometriosis was composed of three types of cells, none of which had any cilia. These findings were observed in continuity with adjacent normal mesothelial cells. No characteristic structure of the endometrial surface was observed for the bluish lesion, but the gland surface of endometriosis located in the subperitoneal stroma initially had ciliated cells. The immunoreactions in both the columnar mesothelial cells with surface peritoneal infoldings and the glands of endometriotic tissues were similar to those of normal endometrial glands, but different from those of normal mesothelial cells. Pelvic endometriosis might originate by a process of metaplasia from the pelvic peritoneum.
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Cited by (29)
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- Age-dependent phenotypes of ovarian endometriomas 2022
- Pathogenesis of Bowel Endometriosis 2020
- Mesothelial Cells Participate in Endometriosis Fibrogenesis Through Platelet-Induced Mesothelial-Mesenchymal Transition 2020
- Rodent Models of Experimental Endometriosis: Identifying Mechanisms of Disease and Therapeutic Targets 2018
- Menstrual endometrial supernatant may induce stromal endometriosis in baboons 2014
- The effect of macrophages on fibroblast activity and lesion development in mouse models of endometriosis. 2014
- Peritoneal, Ovarian, and Rectovaginal Endometriosis are Three Different Entities 2011
- Models of Endometriosis: Animal Models I – Rodent‐Based Chimeric Models 2011
- Immune interactions in endometriosis 2011
- Pathophysiology of Infertility in Endometriosis 2011
- Ultrastructure of ectopic peritoneal lesions from women with endometriosis, including observations on the contribution of coelomic mesothelium 2008
- Immunopathogenesis of pelvic endometriosis: role of hepatocyte growth factor, macrophages and ovarian steroids 2008
- Endometriomas are more frequent on the left side 2007
- Initial endometriosis showing direct morphologic evidence of metaplasia in the pathogenesis of ovarian endometriosis 2005
- Contribution to the physiopathology, symptomatology and treatment of deep infiltrating endometriosis 2004
- Laparoscopic excision of deep endometriosis 2004
- What we have learned from isolated cells from human ovary? 2003
- The concept of ‘adenomyotic disease of the retroperitoneal space’ is born 2001
- Theories of endometriosis 2001
- Endometriosis, Endometrioma, and the Problem of Adhesions 2000
- Coelomic metaplasia theory of endometriosis: evidence from in vivo studies and an in vitro experimental model 1999
- A novel in vitro experimental model for ovarian endometriosis: the three-dimensional culture of human ovarian surface epithelial cells in collagen gels 1999
- Peritoneal endometriotic lesions differentially express a haptoglobin-like gene 1999
- Expression of vimentin and cytokeratin in eutopic and ectopic endometrium of women with adenomyosis and ovarian endometrioma 1998
- Expression of estrogen and progesterone receptors in endometrium and peritoneal endometriosis: an immunohistochemical and in situ hybridization study 1997
- Peritoneal endometriosis, ovarian endometriosis, and adenomyotic nodules of the rectovaginal septum are three different entities 1997
- Etiopathology of endometriosis 1997
- Stereometric evaluation of peritoneal endometriosis and endometriotic nodules of the rectovaginal septum 1996
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