Endometrial patterns during danazol and buserelin therapy for endometriosis: comparative structural and ultrastructural study

L Fedele, Luigi Fedele, Fedele L, M Marchini, Maurizio Marchini, Marchini M, Stefano Bianchi, Bianchi S, S Bianchi, Baglioni A, A. Baglioni, L Bocciolone, Bocciolone L, Luca Bocciolone, Nava S, S Nava, Santiago Nava
Obstetrics and gynecology · 1990 · vol. 76(1) , pp. 79–84 · PMID:2113661 · W185805025
RCT OA: closed CC0 ⤵ 13 in-corpus citations
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⚙ AI-generated summary by gemini-2.5-flash-lite, 2026-06-08 ⓘ

Danazol therapy induced a progestational effect and hypotrophy in the endometrium, while buserelin resulted in inactive mucosa, with both drugs causing noncyclicity and hypotrophy through different mechanisms.

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Abstract

We studied endometrial structure and ultrastructure in serial biopsy specimens from patients with endometriosis treated with danazol (N = 19) or intranasal buserelin (N = 13) for 6 months. Biopsies were performed before and at 3 and 6 months of treatment. The specimens were studied by light, scanning, and transmission electron microscopy. Six morphometric indices were evaluated. Danazol produced a progestational effect on endometrial glands and stroma associated with marked hypotrophy of the mucosa, and buserelin treatment resulted in weakly proliferative or inactive mucosa. Both drugs induced noncyclicity and hypotrophy of endometrium although with different mechanisms of action, and it is suggested that they may have similar effects on ectopic endometrium. Because the atrophic effect of danazol appeared earlier than that of buserelin, the former could be recommended for short-term therapy.

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Condition tags

endometriosis

MeSH descriptors

Buserelin Danazol Endometriosis Endometrium Pregnadienes Adult Adult Buserelin Buserelin Danazol Danazol Endometriosis Endometriosis Endometriosis Endometrium Endometrium Endometrium Endometrium Estradiol Estradiol

Citation neighborhood (2-hop)

Papers in the corpus that this work cites (lower rings, blue) and that cite this one (upper rings, green). Dot size scales with the paper's in-corpus citation count — bigger dot = more influential within the endo/adeno field. Click a dot to open that paper. Outer rings show 2-hop neighbours — papers reached through the immediate citers/citees. [ collapse to 1-hop ]

Cited by (12)

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