Morphologic Patterns of Human Endometrial Epithelium in Women with Uterine Myomata Treated with Leuprorelin Acetate

Vittorio Palmara; Onofrio Triolo; V. Benedetto; Carmela Lo Re; Emanuele Sturlese; Giovanni Retto; Giuseppe Santoro

doi:10.1159/000264633

Morphologic Patterns of Human Endometrial Epithelium in Women with Uterine Myomata Treated with Leuprorelin Acetate

Vittorio Palmara, Onofrio Triolo, V. Benedetto, Carmela Lo Re, Emanuele Sturlese, Giovanni Retto, Giuseppe Santoro

In: Gynecologic and Obstetric Investigation · 2009 · vol. 69(2) , pp. 131–135 · doi:10.1159/000264633 · PMID:19996602 · W2067189705

article OA: closed CC0

View on OpenAlex View on PubMed View at publisher

⚙ AI-generated summary by gemini-2.5-flash-lite, 2026-06-07 ⓘ

Leuprorelin acetate treatment induced a uniform regression of the uterine mucosa after six months, but a near-normal endometrium was observed after only two months.

One-sentence paraphrase of the abstract; not a substitute for reading it. No clinical advice. How this works

Abstract

AIM: We studied morphologic modifications of the endometrium induced by leuprorelin acetate, a gonadotropin-releasing hormone agonist, in women with uterine myomata. METHODS: Transmission and scanning electron microscopy observations were performed after 2 or 6 cycles of therapy (every 28 days). RESULTS: A near-normal endometrium was observed after 2 months of therapy, while treatment with 6 cycles of leuprorelin acetate induced a uniform morphologic regression of the uterine mucosa. CONCLUSIONS: The study demonstrates that leuprorelin acetate induces a unique and time-dependent regression of the endometrial mucous membrane.

My notes (saved in your browser only)

Citation neighborhood (sparse)

Too few in-corpus citations on either side for a chart; here are the lists.

Cites (4)

References (19)

Cell growth effects of leuprolide on cultured endometrioma cells. via openalex
Endometrial patterns during danazol and buserelin therapy for endometriosis: comparative structural and ultrastructural study. via openalex
Long-term pituitary down-regulation before in vitro fertilization (IVF) for women with endometriosis via openalex
Prospective randomized study comparing the GnRH-agonist leuprorelin acetate and the gestagen lynestrenol in the treatment of severe endometriosis via openalex
doi:10.1016/s0015-0282(03)00362-5 via openalex
doi:10.1177/107155760301000105 via openalex
W2307451756 via openalex
W2410164096 via openalex
W2412594395 via openalex
doi:10.1126/science.100883 via openalex
doi:10.1083/jcb.17.1.208 via openalex
doi:10.1016/s0889-8545(02)00057-8 via openalex
doi:10.1016/s0015-0282(16)59289-9 via openalex
doi:10.1016/s0188-4409(01)00331-9 via openalex
doi:10.1016/j.fertnstert.2008.07.1744 via openalex
doi:10.1080/0144361031000153765 via openalex
doi:10.1517/13543784.16.11.1851 via openalex
doi:10.1034/j.1600-0412.2003.00049.x via openalex
doi:10.1016/s1074-3804(05)60254-x via openalex

Source provenance

openalex: last seen: 2026-05-11T06:12:37.668444+00:00
unpaywall: last seen: 2026-08-21T06:37:11.537704+00:00

License: CC0 · commercial use OK

[1] Long-term pituitary down-regulation before in vitro fertilization (IVF) for women with endometriosis 2006

[2] Prospective randomized study comparing the GnRH-agonist leuprorelin acetate and the gestagen lynestrenol in the treatment of severe endometriosis 2001

[3] Endometrial patterns during danazol and buserelin therapy for endometriosis: comparative structural and ultrastructural study. 1990

[4] Cell growth effects of leuprolide on cultured endometrioma cells. 2007