Morphologic patterns of human endometrial epithelium in women with uterine myomata treated with leuprorelin acetate

Vittorio Palmara; Onofrio Triolo; V. Benedetto; Vincenzo Benedetto; Carmela Lo Re; Emanuele Sturlese; Giovanni Retto; Giuseppe Santoro

doi:10.1159/000264633

Morphologic patterns of human endometrial epithelium in women with uterine myomata treated with leuprorelin acetate

Vittorio Palmara, Onofrio Triolo, V. Benedetto, Vincenzo Benedetto, Carmela Lo Re, Emanuele Sturlese, Giovanni Retto, Giuseppe Santoro

Gynecologic and obstetric investigation · 2009 · vol. 69(2) , pp. 131–135 · doi:10.1159/000264633 · PMID:19996602 · W2067189705

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Leuprorelin acetate treatment induced a uniform regression of the uterine mucosa after six months, but a near-normal endometrium was observed after only two months.

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Abstract

AIM: We studied morphologic modifications of the endometrium induced by leuprorelin acetate, a gonadotropin-releasing hormone agonist, in women with uterine myomata. METHODS: Transmission and scanning electron microscopy observations were performed after 2 or 6 cycles of therapy (every 28 days). RESULTS: A near-normal endometrium was observed after 2 months of therapy, while treatment with 6 cycles of leuprorelin acetate induced a uniform morphologic regression of the uterine mucosa. CONCLUSIONS: The study demonstrates that leuprorelin acetate induces a unique and time-dependent regression of the endometrial mucous membrane.

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MeSH descriptors

Antineoplastic Agents, Hormonal Endometrium Gonadotropin-Releasing Hormone Leiomyoma Leuprolide Uterine Neoplasms Adult Antineoplastic Agents, Hormonal Endometrium Endometrium Endometrium Female Gonadotropin-Releasing Hormone Humans Leiomyoma Leiomyoma Leiomyoma Leuprolide Microscopy, Electron, Scanning Microscopy, Electron, Transmission

Citation neighborhood (sparse)

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Cites (4)

References (19)

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[1] Long-term pituitary down-regulation before in vitro fertilization (IVF) for women with endometriosis 2006

[2] Prospective randomized study comparing the GnRH-agonist leuprorelin acetate and the gestagen lynestrenol in the treatment of severe endometriosis 2001

[3] Endometrial patterns during danazol and buserelin therapy for endometriosis: comparative structural and ultrastructural study 1990

[4] Cell growth effects of leuprolide on cultured endometrioma cells 2007