GnRH analogue remarkably down-regulates inflammatory proteins in peritoneal fluid proteome of women with endometriosis
Observational
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⤵ 27 in-corpus citations
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GnRH analogue treatment of women with endometriosis significantly down-regulated multiple inflammatory proteins in peritoneal fluid compared to untreated patients.
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Abstract
OBJECTIVE: To determine the changes in the peritoneal fluid proteome of women with endometriosis determined by the administration of gonadotropin-releasing hormone analogues (GnRH-a).
STUDY DESIGN: Peritoneal fluid samples were collected during laparoscopy from patients under GnRH-a and from women who did not receive any type of hormonal treatment in the 6 months before surgery. Samples were subjected to 2-D gel electrophoresis and compared by computerized analysis. Protein spots differentially expressed between the study groups were identified by liquid chromatography tandem mass spectrometry.
RESULTS: More than 470 protein spots were analyzed. Several proteins with significant alterations were found. The down-regulated molecules were isoforms of alpha 2-HS glycoprotein, alpha 1-antitrypsin, S100-A8, haptoglobin alpha chain and vitamin D-binding protein. No protein spot had significantly higher expression in peritoneal fluid of women under GnRH-a than in untreated patients.
CONCLUSION: Several inflammatory molecules present in peritoneal fluid are down-regulated during treatment with GnRH-a; administration of this drug reduces the inflammation in the peritoneal cavity.
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Cited by (27)
- Safety of current strategies to manage moderate to severe pain in patients with endometriosis 2025
- IVF Stimulation Protocols and Outcomes in Women with Endometriosis 2024
- Does Gonadotropin-Releasing Hormone Agonist Administration Before Assisted Reproduction Techniques Improve Pregnancy Rates in Women With Endometriosis? 2024
- Iron metabolism markers in peritoneal fluid of patients with endometriosis: systematic review and meta-analysis 2024
- Retrospective analysis of the endometrial preparation protocols for frozen-thawed embryo transfer cycles in women with endometriosis 2023
- Controlled ovarian stimulation for endometriosis patients with ultra-long GnRH-agonist or GnRH-antagonist protocols: A retrospective study by propensity score matching 2023
- Antibiotic Therapy and Vaginal Microbiota Transplantation Reduce Endometriosis Disease Progression in Female Mice via NF-κB Signaling Pathway 2022
- Effect of Prolonged GnRH Agonist Therapy Prior to Frozen Embryo Transfer on IVF-ET Outcome in Patients with and without Endometrioma Surgery 2022
- Urinary Biomarkers for Detection of Clinical Endometriosis or Adenomyosis 2022
- The effect of vitamin D supplementation on clinical symptoms and metabolic profiles in patients with endometriosis 2021
- The effectiveness of different down-regulating protocols on in vitro fertilization-embryo transfer in endometriosis: a meta-analysis 2020
- Association between vitamin D and endometriosis: a systematic review 2019
- Pregnancy following robot-assisted laparoscopic partial cystectomy and gonadotropin-releasing hormone agonist treatment within three months in an infertile woman with bladder endometriosis 2018
- Does the type of GnRH analogue used, affect live birth rates in women with endometriosis undergoing IVF/ICSI treatment, according to the rAFS stage? 2018
- GnRH agonist administration prior to embryo transfer in freeze-all cycles of patients with endometriosis or aberrant endometrial integrin expression 2017
- Pituitary suppression before frozen embryo transfer is beneficial for patients suffering from idiopathic repeated implantation failure 2016
- Endometriosis-Related Infertility: The Role of the Assisted Reproductive Technologies 2015
- Urine, peritoneal fluid and omental fat proteomes of reproductive age women: Endometriosis-related changes and associations with endocrine disrupting chemicals 2014
- Aromatase and endometriosis: estrogens play a role 2014
- Endometriosis and assisted reproductive technologies: maximizing outcomes 2013
- The antibody-mediated targeted delivery of interleukin-10 inhibits endometriosis in a syngeneic mouse model 2011
- Diagnosis of Endometriosis: Proteomics 2011
- Innovations in conservative endometriosis treatment: an updated review 2011
- New insights into the pathophysiology of endometriosis: from chronic inflammation to danger signal 2010
- Current pharmacotherapy for endometriosis 2010
- The threshold for laparoscopy for pelvic pain 2010
- Gonadotropin-releasing hormone agonist and add-back therapy: what do the data show? 2010
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- europepmc
- last seen: 2026-10-24T06:12:55.650802+00:00
- openalex
- last seen: 2026-06-10T17:14:06.276822+00:00
- pubmed
- last seen: 2026-10-08T21:06:31.728877+00:00
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