Future developments in the medical treatment of abnormal uterine bleeding: what can we expect?

James A. Simon, Simon JA
Menopause (New York, N.Y.) · 2011 · vol. 18(4) , pp. 468–472 · doi:10.1097/gme.0b013e3182127b53 · PMID:21701433 · W2000539483
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⚙ AI-generated summary by gemini-2.5-flash-lite, 2026-06-12 ⓘ

This review discusses the obstacles and current therapies for abnormal uterine bleeding, highlighting the slow development of new treatments due to cost, regulatory barriers, comorbidities, and measurement challenges.

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⚙ AI-generated deep summary by qwen3.7-flash, 2026-09-06 · read from full text ⓘ

This review examines the significant barriers hindering the development of new medical therapies for abnormal uterine bleeding, including stringent regulatory requirements for long-term safety and the high costs associated with large study samples. The author notes that common comorbidities such as adenomyosis, leiomyomata, and bleeding diatheses further complicate clinical trials by necessitating larger cohorts to ensure accurate data collection. Additionally, the inherent difficulty in accurately measuring menstrual blood loss presents a persistent challenge for novel drug development in this field. Relevance to endometriosis: adenomyosis is explicitly cited as a complicating comorbidity that impacts clinical development for abnormal uterine bleeding, though the paper does not focus on endometriosis or adenomyosis as primary subjects.

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Abstract

New therapies for abnormal uterine bleeding have been slow to reach the marketplace for a variety of reasons. These reasons include the availability of cost-effective therapies already available and the extraordinarily difficult and expensive regulatory barriers emphasizing long-term safety. Common comorbidities like bleeding diatheses, adenomyosis, and leiomyomata further complicate clinical development, necessitating large study samples and making it more expensive. Even the accurate measurement of menstrual blood loss adds an additional hindrance to novel drug development. These obstacles and the currently available therapies will be reviewed in the context of developing new methods for approaching this complicated and prevalent clinical problem.
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Future developments in the medical treatment of abnormal uterine bleeding what can we expect? - James A. Simon New therapies for abnormal uterine bleeding have been slow to reach the marketplace for a variety of reasons. These reasons include the availability of cost-effective therapies already available and the extraordinarily difficult and expensive regulatory barriers emphasizing long-term safety. Common comorbidities like bleeding diatheses, adenomyosis, and leiomyomata further complicate clinical development, necessitating large study samples and making it more expensive. Even the accurate measurement of menstrual blood loss adds an additional hindrance to novel drug development. These obstacles and the currently available therapies will be reviewed in the context of developing new methods for approaching this complicated and prevalent clinical problem.

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Condition tags

adenomyosis

MeSH descriptors

Metrorrhagia Female Female Forecasting Forecasting Humans Humans Metrorrhagia Metrorrhagia

Citation neighborhood (2-hop)

Papers in the corpus that this work cites (lower rings, blue) and that cite this one (upper rings, green). Dot size scales with the paper's in-corpus citation count — bigger dot = more influential within the endo/adeno field. Click a dot to open that paper. Outer rings show 2-hop neighbours — papers reached through the immediate citers/citees. [ collapse to 1-hop ]

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