Low-dose aspirin can downregulate progesterone resistance and increase the expression of LIF in endometriosis during the implantation window

Lihui Wang, Wang L, Zhang J, Jing Zhang, Hui Zhang, Zhang H, Li R, Rui Li, Chunyan Li, Li C, Zhao X, Xingbo Zhao, Xingbo Ζhao, Mingjiang Li, Li M
Gynecological endocrinology : the official journal of the International Society of Gynecological Endocrinology · 2021 · vol. 37(8) , pp. 725–729 · doi:10.1080/09513590.2021.1918663 · PMID:33974468 · W3160880656
Lab / animal OA: closed CC0 ⤵ 3 in-corpus citations
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Low-dose aspirin treatment in endometriosis rats downregulated progesterone resistance and increased leukemia inhibitory factor (LIF) in the endometrium and serum, potentially improving endometrial receptivity.

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Abstract

AIM: Study the effect of low-dose aspirin on the endometrial receptivity in endometriosis rat models. MATERIALS AND METHODS: This study is to explore the expressions of progesterone receptor and LIF among three groups of endometriosis rat models: control group (n = 12), EMs group (n = 15), and aspirin group (n = 17). The expressions of progesterone receptor (PR), PRA, PRB, and leukemia inhibitory factor receptor (LIFR) in eutopic endometrium were determined using immunohistochemistry technology, western blot, and qRT-PCR. The levels of LIF in eutopic endometrium and serum were detected by western blot, qRT-PCR, and ELISA. RESULTS: The expressions of PR, PRA, and PRB protein were significantly increased in the eutopic endometrium after low-dose aspirin treatment, and the level of PRB mRNA was also increased while the ratio of PRA/PRB mRNA was decreased in the eutopic endometrium. The levels of LIF in eutopic endometrium and serum were increased compared with the untreated endometriosis rats. However, the expression of LIFR was not statistically different among the three groups. CONCLUSIONS: The results suggest that the low-dose aspirin treatment could downregulate progesterone resistance and increase the expression of LIF of endometriosis rats during the implantation window, which could improve endometrial receptivity and enhance the pregnant rate of endometriosis. It may provide a potential treatment method for endometriosis-related infertility.

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Condition tags

endometriosisinfertility

MeSH descriptors

Aspirin Aspirin Aspirin Embryo Implantation Embryo Implantation Embryo Implantation Endometriosis Endometriosis Endometriosis Endometriosis Endometriosis Leukemia Inhibitory Factor Leukemia Inhibitory Factor Leukemia Inhibitory Factor Leukemia Inhibitory Factor Leukemia Inhibitory Factor Progesterone Progesterone Progesterone Receptors, Progesterone

Citation neighborhood (2-hop)

Papers in the corpus that this work cites (lower rings, blue) and that cite this one (upper rings, green). Dot size scales with the paper's in-corpus citation count — bigger dot = more influential within the endo/adeno field. Click a dot to open that paper. Outer rings show 2-hop neighbours — papers reached through the immediate citers/citees. [ collapse to 1-hop ]

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