Pro-inflammatory M1/Th1 type immune network and increased expression of TSG-6 in the eutopic endometrium from women with endometriosis

Matteo M, M. Matteo, E. Cicinelli, Cicinelli E, Ettore Cicinelli, M. Neri, Margherita Neri, Carrubba R, R. Carrubba, Carpagnano FA, F A Carpagnano, Francesca Anna Carpagnano, F Romeo, Franca Romeo, Romeo F, G Scutiero, Gennaro Scutiero, Pantaleo Greco, P Greco, Cecília Garlanda, C Garlanda, G. Vendemiale, Gianluigi Vendemiale, Vendemiale G, Paolo Emanuele Levi-Setti, P E Levi Setti, Gaetano Serviddio, G Serviddio, Serviddio G
European journal of obstetrics, gynecology, and reproductive biology · 2017 · vol. 218 , pp. 99–105 · doi:10.1016/j.ejogrb.2017.08.014 · PMID:28963923 · W2751548535
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This study investigated the pro-inflammatory M1/Th1 immune network and TSG-6 expression in the eutopic endometrium of women diagnosed with endometriosis.

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Abstract

ObjectiveThe study aimed to explore the type 1 and type 2 cytokines expression in the endometrium from women affected by endometriosis compared to controls. The expression of TSG-6, a multifunctional protein involved in several inflammatory disease, was also evaluated. Study Design SETTING: Experimental clinical study.Patients10 patients affected by endometriosis and 11 controls.InterventionsPatients underwent to an ultrasound transvaginal examination and a diagnostic hysteroscopy in order to exclude any uterine abnormality. All patients underwent endometrial biopsy using a Novak's curette.Main outcome measuresThe endometrial expression of type 1 (IL- 1 β TNF-α, IL-8) and type 2 (IL-10) cytokines, and of TSG-6 was evaluated by immunohistochemistry and by real time PCR. The expression of TSG-6 was confirmed by western blot.ResultsResults of PCR analysis and of immunohistochemistry revealed an increased expression of IL-1β, TNF-α, IL-8 and of TSG-6 in the endometrium of endometriosic patients. IL-10 expression did not show any difference.ConclusionsAn increased expression of pro-inflammatory type 1 cytokines was demonstrated in the endometrium from endometriosic patients, suggesting an endometrial environment harmful for implantation due to the prevalence of Th1 related immunity. An increased expression of TSG-6 was also demonstrated for the first time. Our findings concur to better define the inflammatory imbalance and the abnormal endometrial receptivity, reported in literature, of the eutopic endometrium of women affected by endometriosis.

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Condition tags

endometriosis

MeSH descriptors

Endometriosis Endometrium Infertility, Female Adult Blotting, Western Case-Control Studies Cell Adhesion Molecules Cell Adhesion Molecules Cell Adhesion Molecules Endometriosis Endometrium Endometrium Female Gene Expression Regulation Humans Infertility, Female Inflammation Mediators Inflammation Mediators Interleukin-10 Interleukin-10

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