Cone biopsy causes cervical endometriosis and tubo-endometrioid metaplasia

Ismail SM, S M Ismail
Histopathology · 1991 · vol. 18(2) , pp. 107–114 · doi:10.1111/j.1365-2559.1991.tb01452.x · PMID:2010178 · W2085787528
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This study found that cervical endometriosis and tubo-endometrioid metaplasia are common complications of cone biopsy, occurring in 69% of post-conization cervices due to aberrant differentiation after injury.

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Abstract

Cervices from 42 hysterectomies performed from 1 to 91 months (mean 12.2) following conization were re-examined in order to assess the possible effects of post-traumatic regeneration on the endocervix. Twenty-nine (69%) showed a continuum of abnormalities in which the shared finding was the presence of tubo-endometrioid glands, accompanied in many cases by varying amounts of endometrial-type stroma. Thus, 18 post-conization cervices (43%) showed endometriosis, and a further 11 cases (26%) contained tubo-endometrioid glands without demonstrable endometrial-type stroma. These abnormalities were situated at the healed cone biopsy site, either superficially within the new transformation zone and/or within the cone biopsy scar. Post-conization cervical endometriosis occurred from 2 to 91 months (mean 17.8) and tubo-endometrioid metaplasia 2-24 months (mean 11.0) after the cone biopsy. It is concluded that cervical endometriosis and tubo-endometrioid metaplasia are common complications of conization, and that they represent aberrant differentiation following injury. The demonstration of endometriosis and tubo-endometrioid metaplasia in 69% of post-conization cervices has implications for the interpretation of cervical biopsies and smears from this group of women.

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Condition tags

endometriosis

MeSH descriptors

Biopsy Cervix Uteri Cervix Uteri Endometriosis Uterine Cervical Neoplasms Adult Adult Biopsy Biopsy Biopsy Cervix Uteri Cervix Uteri Endometriosis Endometriosis Epithelium Epithelium Epithelium Female Female Humans

Citation neighborhood (2-hop)

Papers in the corpus that this work cites (lower rings, blue) and that cite this one (upper rings, green). Dot size scales with the paper's in-corpus citation count — bigger dot = more influential within the endo/adeno field. Click a dot to open that paper. Outer rings show 2-hop neighbours — papers reached through the immediate citers/citees. [ collapse to 1-hop ]

References (28)

Cited by (29)

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