A Rare Case of the Cervical Endometriosis and Overview of the Literature

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This case report details a rare instance of cervical endometriosis presenting with pelvic pain and menstrual irregularity, alongside endometrioma and adenomyosis, and includes a literature overview to describe the condition's changing clinical landscape.

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This paper reports a rare case of cervical endometriosis in a patient presenting with pelvic pain and menstrual irregularity, in which an endometrioma and adenomyosis were identified and confirmed through histopathological evaluation of the specimen. The authors also provide an overview of cervical endometriosis, distinguishing primary disease confined to the cervix from secondary disease extending from pelvic sites, and describing both superficial (often diagnosed via fine-needle aspiration, colposcopy, and cervical biopsy after abnormal cytology) and deep endometriosis presentations. They note that symptoms can range from incidental/asymptomatic findings to severe events such as life-threatening hemorrhage, and they distinguish clinical definitions and diagnostic pitfalls, including potential misclassification on PAP smears. As a case report and literature overview, the main limitation is its inability to establish broader causal or prevalence estimates. This paper is centrally about endometriosis — it specifically details a cervical endometriosis case with histologic confirmation of coexisting adenomyosis.

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Abstract

Cervical endometriosis is an uncommon form of endometriosis that is frequently diagnosed incidentally during histopathological evaluation of a hysterectomy or cervical biopsy specimens. Although some cases may be asymptomatic, the symptoms in some patients range from life-threatening hemorrhage to severe chronic pelvic pain. In asymptomatic patients, no further intervention might be required apart from observation and follow-up; however, patients with significant symptoms will require surgery. Primary cervical endometriosis is defined as presence of endometrial tissue on the anterior lip of the cervix, limited to the cervix surface and not extending below the squamous epithelium. Secondary cervical endometriosis is more common than the primary type and describes the disease extensions from the pelvis, or usually the rectovaginal septum. Superficial endometriosis is usually diagnosed by fine-needle aspiration, colposcopy, and cervical biopsy after a routine cervical smear, as endometrial cells detected during a PAP smear may be mistakenly removed as atypical glandular cells. Deep endometriosis may cause pelvic pain, vaginal bleeding, and spotting. In this case report, we present a rare case of cervical endometriosis, characterized by pelvic pain and menstrual irregularity, with endometrioma and adenomyosis, confirmed by histopathological evaluation of the specimen. A summary of the cervical endometriosis cases overview has been made to describe the changing clinical landscape of this rare condition.
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Abstract

Cervical endometriosis is an uncommon form of endometriosis that is frequently diagnosed incidentally during histopathological evaluation of a hysterectomy or cervical biopsy specimens. Although some cases may be asymptomatic, the symptoms in some patients range from life-threatening hemorrhage to severe chronic pelvic pain. In asymptomatic patients, no further intervention might be required apart from observation and follow-up; however, patients with significant symptoms will require surgery. Primary cervical endometriosis is defined as presence of endometrial tissue on the anterior lip of the cervix, limited to the cervix surface and not extending below the squamous epithelium. Secondary cervical endometriosis is more common than the primary type and describes the disease extensions from the pelvis, or usually the rectovaginal septum. Superficial endometriosis is usually diagnosed by fine-needle aspiration, colposcopy, and cervical biopsy after a routine cervical smear, as endometrial cells detected during a PAP smear may be mistakenly removed as atypical glandular cells. Deep endometriosis may cause pelvic pain, vaginal bleeding, and spotting. In this case report, we present a rare case of cervical endometriosis, characterized by pelvic pain and menstrual irregularity, with endometrioma and adenomyosis, confirmed by histopathological evaluation of the specimen. A summary of the cervical endometriosis cases overview has been made to describe the changing clinical landscape of this rare condition. Similar content being viewed by others Data Availability As a hospital policy, before each procedure, written informed consent was obtained from each patient that gave permission to use the medical data anonymously for future studies. Change history 04 May 2023 A Correction to this paper has been published: https://doi.org/10.1007/s43032-023-01254-4

References

Ata B, Ates U, Usta T, Attar E. Cervical endometriosis, a case presenting with ıntractable spotting. MedGenMed. 2005;7:64. Veiga-Ferreira MM, Leiman G, Dunbar F, Margolius KA. Cervical endometriosis: facilitated diagnosis by fine needle aspiration cytologic testing. Am J Obstet Gynecol. 1987;157:849–56. https://doi.org/10.1016/S0002-9378(87)80070-4. Ismail SM. Cone biopsy causes cervical endometriosis and tubo-endometrioid metaplasia. Histopathology. 1991;18:107–14. https://doi.org/10.1111/J.1365-2559.1991.TB01452.X. Siddal RS, Mack HC. Primary endometriosis of the vaginal portion of the cervix uteri. Am J Obstet Gynecol. 1949;58:765–9. https://doi.org/10.1016/S0002-9378(16)39234-1. Swetha P, Nagashree U, Kondammal R. A rare presentation of deep infiltrating cervical endometriosis mimicking cervical cancer. Int J Reprod Contracept Obstet Gynecol. 2020;9:3903–5. https://doi.org/10.18203/2320-1770.IJRCOG20203881. Félix A, Nogales FF, Arias-Stella J. Polypoid endometriosis of the uterine cervix with Arias-Stella reaction in a patient taking phytoestrogens. Int J Gynecol Pathol. 2010;29:185–8. https://doi.org/10.1097/PGP.0B013E3181B7015E. Lundeen SJ, Horwitz CA, Larson CJ, Stanley MW. Abnormal cervicovaginal smears due to endometriosis: a continuing problem. Diagn Cytopathol. 2002;26:35–40. https://doi.org/10.1002/DC.10038. Selo-Ojeme D, Freeman-Wang T, Khan NH. Post-coital bleeding: a rare and unusual presentation of cervical endometriosis. Arch Gynecol Obstet. 2006;273:370–3. https://doi.org/10.1007/S00404-005-0034-X. Mendoza GO, Castañón FJM, Hernández M, Maguregui SCO, Orozco VMM. [Deep cervical endometriosis causing profuse vaginal bleeding. Case report and literature review]. Ginecol Obstet Mex 2009;77(11)518–22. https://pubmed.ncbi.nlm.nih.gov/20085136/. Accessed 19 Oct 2022 Shaw RW. An Atlas of Endometriosis First edition. Parthenon Publishing, Carnforth, UK. 1993. https://www.abebooks.com/first-edition/Atlas-Endometriosis-Shaw-R-W-Parthenon/1317788171/bd#&gid=1&pid=1. Accessed 9 Oct 2022 Matoba Y, Tsuji K, Morisada T, Takahashi M, Kobayashi Y, Nakamura M, Banno K, Aoki D. Massive hemorrhage due to cervical endometriotic cyst rupture: two case reports and a literature review. Am J Case Rep. 2021;22:e934120. https://doi.org/10.12659/AJCR.934120 Wong FWS, Lim CED, Karia S, Santos L. Cervical endometriosis: case series and review of literature. J Obstet Gynaecol Res. 2010;36:916–9. https://doi.org/10.1111/J.1447-0756.2010.01209.X. Li J, Liu R, Tang S, Feng F, Liu C, Wang L, Zhao W, Zhang T, Yao Y, Wang X, Sun C. Impact of endometriosis on risk of ovarian, endometrial and cervical cancers: a meta-analysis. Arch Gynecol Obstet. 2018;299:35–46. https://doi.org/10.1007/S00404-018-4968-1. Matalliotakis M, Matalliotaki C, Zervou MI, Krithinakis K, Kalogiannidis I, Goulielmos GN. Coexistence of cervical endometriosis with premalignant and malignant gynecological pathologies: report on a series of 27 cases. Women Health. 2021;61:896–901. https://doi.org/10.1080/03630242.2021.1991073. Baker PM, Clement PB, Bell DA, Young RH. Superficial endometriosis of the uterine cervix: a report of 20 cases of a process that may be confused with endocervical glandular dysplasia or adenocarcinoma in situ . Int J Gynecol Pathol. 1999;18(3):198–205. https://pubmed.ncbi.nlm.nih.gov/12090586/. Accessed 9 Oct 2022 Bozdag G, Igci N, Calis P, Ayhan B, OzelDemiralp D, Mumusoglu S, Yarali H. Examination of cervical swabs of patients with endometriosis using Fourier transform infrared spectroscopy. Arch Gynecol Obstet. 2019;299:1501–8. https://doi.org/10.1007/S00404-019-05105-Z. Wang S, Li XC, Lang JH. Cervical endometriosis: clinical character and management experience in a 27-year span. Am J Obstet Gynecol. 2011;205:452.e1-452.e5. https://doi.org/10.1016/J.AJOG.2011.06.070. Hashimi SA, Bhatia Y, Singh S. Polypoid endometriosis of cervix: a case report. Gynecol Obstet Reprod Med. 2023;29(1):72-4. https://doi.org/10.21613/GORM.2021.1197. Park HM, Lee SS, Eom DW, Kang GH, Yi SW, Sohn WS. Endometrioid adenocarcinoma arising from endometriosis of the uterine cervix: a case report. J Korean Med Sci. 2009;24:767–71. https://doi.org/10.3346/JKMS.2009.24.4.767. Author information Authors and Affiliations Corresponding author Ethics declarations Consent to Participate As a hospital policy, before each procedure, written informed consent was obtained from each patient that gave permission to use the medical data anonymously for future studies. Ethics committee approval was not required as this study was a case report. Conflict of Interest The authors declare no competing interests. Additional information Publisher's Note Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations. Rights and permissions Springer Nature or its licensor (e.g. a society or other partner) holds exclusive rights to this article under a publishing agreement with the author(s) or other rightsholder(s); author self-archiving of the accepted manuscript version of this article is solely governed by the terms of such publishing agreement and applicable law. About this article Cite this article Atalay Mert, S., Dilbaz, B., Ercan, E.E. et al. A Rare Case of the Cervical Endometriosis and Overview of the Literature. Reprod. Sci. 30, 2882–2886 (2023). https://doi.org/10.1007/s43032-023-01238-4 Received: Accepted: Published: Version of record: Issue date: DOI: https://doi.org/10.1007/s43032-023-01238-4

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Condition tags

endometriosischronic_pelvic_pain

MeSH descriptors

Adenomyosis Adenomyosis Adenomyosis Adenomyosis Adenomyosis Adenomyosis Adenomyosis Adenomyosis Adenomyosis Adenomyosis Adenomyosis Adenomyosis Adenomyosis Adenomyosis Adenomyosis Adenomyosis Adenomyosis Adenomyosis Adenomyosis Adenomyosis

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