Long-Term Clinical Outcomes in Diabetic Rhesus Macaques (Macaca mulatta) Treated with Medroxyprogesterone Acetate for Endometriosis

M. Connolly, Connolly MA, Meghan A Connolly, Trentalange M, Mark Trentalange, Caroline J. Zeiss, Zeiss CJ
Comparative medicine · 2016 · vol. 66(4) , pp. 343–8 · PMID:27538865 · PMC4983176 · W2516968934
Other OA: green CC0 ⤵ 2 in-corpus citations
📄 Open PDF View on OpenAlex View on PubMed
⚙ AI-generated summary by gemini-2.5-flash-lite, 2026-06-10 ⓘ

This retrospective study examined 29 rhesus macaques and found that medroxyprogesterone acetate treatment, while associated with worsening trends in lifespan and incident diabetes, did not significantly alter outcomes in animals with diabetes or endometriosis.

One-sentence paraphrase of the abstract; not a substitute for reading it. No clinical advice. How this works

Abstract

Depot medroxyprogesterone acetate (DMPA) is a common medical treatment for endometriosis in NHP. Because DMPA reportedly impairs glucoregulatory function in humans and rhesus macaques, as well as predisposes humans to diabetes mellitus (DM), we performed a retrospective study to further investigate its potential long-term clinical effects in animals with and without DM. Using a cohort of 29 rhesus macaques, we explored the hypotheses that DMPA treatment accelerates the onset of DM and that its use in rhesus macaques with endometriosis worsens clinical outcome measures (lifespan, body weight and body condition score). For both body weight and body condition score, a declining and statistically significant trend in mean values was evident as macaques developed either DM, or endometriosis or both. The addition of DMPA did not significantly alter this pattern. The presence of DM, endometriosis, or DMPA treatment statistically but not clinically significantly increased risk of death. Similarly, the presence of the 2 highly correlated variables endometriosis and DMPA treatment statistically but not clinically significantly increased the risk of incident DM. These results indicate that DMPA treatment was associated with worsening trends in lifespan and incident DM, however these trends did not achieve clinical significance in this cohort.

My notes (saved in your browser only)

Condition tags

endometriosis

MeSH descriptors

Diabetes Complications Endometriosis Macaca mulatta Macaca mulatta Medroxyprogesterone Acetate Monkey Diseases Animals Animals Delayed-Action Preparations Delayed-Action Preparations Diabetes Complications Diabetes Complications Diabetes Complications Endometriosis Endometriosis Endometriosis Endometriosis Female Female Medroxyprogesterone Acetate

Citation neighborhood (2-hop)

Papers in the corpus that this work cites (lower rings, blue) and that cite this one (upper rings, green). Dot size scales with the paper's in-corpus citation count — bigger dot = more influential within the endo/adeno field. Click a dot to open that paper. Outer rings show 2-hop neighbours — papers reached through the immediate citers/citees. [ collapse to 1-hop ]

References (35)

Cited by (2)

Source provenance

europepmc
last seen: 2026-10-17T06:09:56.316927+00:00
openalex
last seen: 2026-06-10T17:14:06.276822+00:00
pubmed
last seen: 2026-10-08T21:18:26.654515+00:00
License: CC0 · commercial use OK