Enhanced expressions of matrix metalloproteinase (MMP)-2 and -9 and vascular endothelial growth factors (VEGF) and increased microvascular density in the endometrial hyperplasia of women with anovulatory dysfunctional uterine bleeding

Xinmei Zhang, Caixia Qi, Jun Lin
Fertility and sterility · 2009 · vol. 93(7) , pp. 2362–2367 · doi:10.1016/j.fertnstert.2008.12.142 · PMID:19249761 · W2110301335
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This study investigated and found enhanced expressions of MMP-2, MMP-9, and VEGF, along with increased microvascular density, in the endometria of women experiencing anovulatory dysfunctional uterine bleeding due to hyperplasia.

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Abstract

OBJECTIVE: To evaluate the roles of endometrial matrix metalloproteinase (MMP)-2 and -9, vascular endothelial growth factors (VEGF), and microvascular density (MVD) in the occurrence of anovulatory dysfunctional uterine bleeding (DUB). DESIGN: A prospective analytical design. SETTING: The obstetrics and gynecology department of an academic training hospital. PATIENT(S): Sixty women with anovulatory DUB and 20 control women. INTERVENTION(S): Endometrial biopsies were obtained for the assessment of immunohistochemical staining of MMP-2 and -9, VEGF, and endometrial MVD using an antibody to CD34. MAIN OUTCOME MEASURE(S): The results were determined through the expressions of MMP-2 and -9, VEGF, and CD34. RESULT(S): The frequencies of MMP-2 and -9 expression in endometrial stroma and of VEGF expression in endometrial glands were all significantly higher in the endometrial hyperplasia of women with anovulatory DUB than they were in the control group. Additionally, the mean score of endometrial MVD was significantly higher in the endometrial hyperplasia of women with anovulatory DUB than it was in the control group. In women with anovulatory DUB, VEGF expression in endometrial glands was statistically correlated with MMP-2 and -9 expressions in endometrial stroma and endometrial MVD. CONCLUSION(S): These results suggest that enhanced expressions of MMP-2 and -9, VEGF, and increased MVD in endometrial hyperplasia may play important roles in the pathogenesis of women with anovulatory DUB.

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MeSH descriptors

Anovulation Endometrial Hyperplasia Endometrium Matrix Metalloproteinase 2 Metrorrhagia Microvessels Vascular Endothelial Growth Factors Anovulation Anovulation Antigens, CD34 Antigens, CD34 Case-Control Studies Cell Count Endometrial Hyperplasia Endometrial Hyperplasia Endometrium Endometrium Female Follicular Phase Follicular Phase

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