Isolation, synthesis, and biological activity of five metabolites of danazol
Other
OA: closed
CC0
⤵ 12 in-corpus citations
AI-generated summary
Five danazol metabolites were isolated from urine and synthesized, but none showed significant pituitary inhibiting activity compared to danazol.
One-sentence paraphrase of the abstract; not a substitute for reading it. No clinical advice. How this works
Abstract
Metabolites of danazol (17 alpha-pregna-2,4-dien-20-yno[2,3-d]isoxazol-17-ol), an orally effective pituitary gonadotropin inhibitory agent devoid of estrogenic and progestational activites, were isolated from urine of a female subject who had taken danzol orally at a dose of 800 mg/day for 7 days, The metabolites isolated were 17-hydroxy-17alpha-pregn-4-en-20-yn-3-one (11), 17-hydroxy-2alpha-(hydroxymethyl)-17alpha-pregn-4-3n-20-yn-3-one (5), 17-hydroxy-2-(hydroxymethyl)-17alpha-pregna-1,4-dien-20-yn-3-one(7), 6beta,17-dihydroxy-2alpha-(hydroxymethyl)-17alphapregn-4-en-20-yn-3-one(8), and 6beta, 17-dihydroxy-2(hydroxymethyl)-17alphapregna-1,4-dien-20yn-3-one(10). None of these metabolites exhibited pituitary inhibiting activity comparable to danazol.
My notes (saved in your browser only)
MeSH descriptors
Citation neighborhood (2-hop)
Papers in the corpus that this work cites (lower rings, blue) and that cite this one (upper rings, green). Dot size scales with the paper's in-corpus citation count — bigger dot = more influential within the endo/adeno field. Click a dot to open that paper. Outer rings show 2-hop neighbours — papers reached through the immediate citers/citees. [ collapse to 1-hop ]
Cited by (12)
- Danazol 2022
- A benefit-risk assessment of medical treatment for uterine leiomyomas 2002
- Prolonged inhibition of normal ovarian cycles in the rat and cynomolgus monkeys following a single s.c. injection of danazol 1997
- A liquid chromatographic method for the determination of danazol in human serum 1990
- Analysis of danazol in serum using high-performance liquid chromatography 1987
- Determination of danazol in pharmaceutical preparations by liquid chromatography 1986
- The effect of danazol on gonadotropin secretion during the follicular phase of the menstrual cycle 1983
- Hormonal and Surgical Management of Pelvic Endometriosis 1982
- Danazol binding to rat androgen, glucocorticoid, progesterone, and estrogen receptors: correlation with biologic activity 1979
- A radioimmumoassay for danazol (17α-Pregna-2,4-Dien-20-Yno[2,3-d]Isoxazol-17-OL) 1978
- Radioimmunoassay for danazol in human and monkey plasma 1978
- ChemInform Abstract: ISOLATION, SYNTHESIS, AND BIOLOGICAL ACTIVITY OF FIVE METABOLITES OF DANAZOL 1977
Source provenance
- openalex
- last seen: 2026-05-10T10:31:59.398892+00:00
- pubmed
- last seen: 2026-10-08T21:49:18.986600+00:00
- unpaywall
- last seen: 2026-10-15T06:24:24.424788+00:00
License: CC0
· commercial use OK