Anti-endometrial lymphocytotoxicity and natural killer cell activity in baboons (Papio anubis and Papio cynocephalus) with endometriosis

D'Hooghe TM, T M D'Hooghe, Thomas D’Hooghe, Jean‐Pierre Y. Scheerlinck, J P Scheerlinck, Scheerlinck JP, Koninckx PR, P R Koninckx, Philippe R. Koninckx, J A Hill, Hill JA, JA Hill, Charanjit S. Bambra, C S Bambra, Bambra CS
Human Reproduction · 1995 · vol. 10(3) , pp. 558–562 · doi:10.1093/oxfordjournals.humrep.a135988 · PMID:7782431 · W2264153209
Other OA: closed CC0 ⤵ 23 in-corpus citations
View on OpenAlex View on PubMed View at publisher
⚙ AI-generated summary by gemini-2.5-flash-lite, 2026-06-07 ⓘ

Lymphocyte-mediated cytotoxicity against endometrial cells was significantly lower in baboons with endometriosis than in normal baboons, but NK cell activity was comparable between groups.

One-sentence paraphrase of the abstract; not a substitute for reading it. No clinical advice. How this works

Abstract

This study was performed to test the hypothesis that anti-endometrial, lymphocyte-mediated cytotoxicity and natural killer (NK) activity are reduced in baboons with endometriosis when compared to animals with a normal pelvis. Lymphocyte-mediated cytotoxicity was determined in 28 baboons (15 with endometriosis, 13 with normal pelvis) and NK cell activity was evaluated in 42 baboons (31 with endometriosis, 11 with normal pelvis). Anti-endometrial lymphocyte-mediated cytotoxicity was determined by a 20 h assay with effector-target ratios of 50:1 and 25:1. The NK activity (K562 cell line as target) was simultaneously measured in all animals during a 4 h assay with effector:target ratios of 200:1, 100:1, 50:1, 25:1, 12:1, 6:1 and 3:1. Statistical analysis was performed using analysis of variance, paired rank, Mann-Whitney, Kruskal-Wallis and Fisher exact tests where appropriate. Lymphocyte-mediated cytotoxicity was significantly lower (P < 0.025) in baboons with endometriosis (mean 5.9 +/- 8.7%, median 0%, range 0-26%) than in animals with a normal pelvis (mean 22.9 +/- 23.0%, median 7%, range 0-78%). This difference could be explained by the absence of cytotoxicity in baboons with moderate to severe endometriosis, probably due to high spontaneous release of 51Cr from labelled target cells. When stricter criteria were used and only animals with a labelling index (maximal/spontaneous release) of > or = 1.7 were analysed (n = 11), the anti-endometrial cytotoxicity was comparable between baboons with and without endometriosis. NK cell activity was also comparable in primates with and without endometriosis. In conclusion, no difference in lymphocyte-mediated cytotoxicity and NK cell activity was observed between baboons with and without endometriosis.

My notes (saved in your browser only)

Condition tags

endometriosis

MeSH descriptors

Cytotoxicity, Immunologic Cytotoxicity, Immunologic Endometriosis Endometrium Killer Cells, Natural Lymphocytes Papio Animals Animals Autoimmunity Autoimmunity Chromium Radioisotopes Chromium Radioisotopes Chromium Radioisotopes Endometriosis Endometriosis Endometrium Endometrium Female Female

Citation neighborhood (2-hop)

Papers in the corpus that this work cites (lower rings, blue) and that cite this one (upper rings, green). Dot size scales with the paper's in-corpus citation count — bigger dot = more influential within the endo/adeno field. Click a dot to open that paper. Outer rings show 2-hop neighbours — papers reached through the immediate citers/citees. [ collapse to 1-hop ]

Cited by (23)

Source provenance

europepmc
last seen: 2026-10-10T06:11:15.153948+00:00
openalex
last seen: 2026-06-04T00:00:01.174412+00:00
pubmed
last seen: 2026-10-08T21:59:01.426159+00:00
unpaywall
last seen: 2026-10-10T06:25:47.132674+00:00
License: CC0 · commercial use OK