The effects of melatonin on endometriotic lesions induced by implanting human endometriotic cells in the first SCID-mouse endometriosis-model developed in Turkey

Narter Yeşildağlar, N Yesildaglar, G. Yıldırım, G Yildirim, Ömer YILDIRIM, O K Yildirim, Rükset Attar, R Attar, Ferda Özkan, F Ozkan, Hatice Akkaya, H Akkaya, Bayram Yılmaz, B Yilmaz
Clinical and experimental obstetrics & gynecology · 2016 · vol. 43(1) , pp. 25–30 · doi:10.12891/ceog2035.2016 · PMID:27048013 · W2473389408
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⚙ AI-generated summary by claude@2026-06, 2026-06-08 ⓘ

Melatonin administration reduced endometriotic lesion size and malondialdehyde levels in a SCID mouse model of endometriosis.

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⚙ AI-generated deep summary by claude@2026-06, 2026-06-10 · read from full text ⓘ

This prospective, randomized, controlled experimental study tested melatonin’s effects on endometriotic lesions in a first “Turkey-developed” SCID-mouse model by implanting human endometriotic cells subcutaneously and administering melatonin (20 mg/kg/day) for four weeks versus no treatment, with all mice receiving exogenous estradiol (50 μg/kg/d twice weekly). After four weeks, lesions were assessed histopathologically and for oxidative stress markers, including MDA and SOD. Melatonin was associated with a lower histopathological score and reduced mean MDA levels, while mean SOD levels were not significantly different between groups. A key limitation noted by the study design is the small number of surviving mice (28 of 30) and the use of an immunodeficient model with exogenous estradiol. This paper is centrally about endometriosis — it evaluates melatonin treatment of experimental endometriotic lesions induced by patient-derived endometriotic cell implants in SCID mice.

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Abstract

OBJECTIVE: To evaluate the effects of melatonin on endometriotic lesions induced by implanting human endometriotic cells in SCID mice. MATERIALS AND METHODS: Prospective, randomized, controlled, experimental study. Experimental Research Center of Yeditepe University (YUDETAM). Thirty female, non-pregnant, nulligravid severe combined immunodeficient (SCID) mice. Endometriotic cells collected from patients with endometriosis were implanted subcutaneously in 30 SCID mice. These mice were randomized into two study groups: in the first group, mice were administered melatonin (20 mg/kg/day) following induction of endometriosis for four weeks; in the second group, nothing was administered. All the mice were given a high dose of exogenous estradiol (50 µg/kg/d, twice weekly). Four weeks after inoculation, necropsies were performed and endometriotic lesions were collected. All the lesions were evaluated histopathologically and the levels of SOD and MDA were assessed in the lesions. RESULTS: Successful implantation was observed in the 28 mice that survived. Mean MDA level was 5.0 ± 1.7 and 8.8 ± 2.6 in the melatonin and control groups, respectively (p = 0.01); mean SOD level was 1.1 ± 0.1 and 1.0 ± 0.1 in the melatonin and control groups, respectively (p = 0.49). Mean histopathological score was lower in the melatonin group (p = 0.04). CONCLUSIONS: Melatonin was effective in the treatment of experimental endometriosis induced in SCID mice.
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Abstract

Objective: To evaluate the effects of melatonin on endometriotic lesions induced by implanting human endometriotic cells in SCID mice. Materials and Methods: Prospective, randomized, controlled, experimental study. Experimental Research Center of Yeditepe University (YUDETAM). Thirty female, non-pregnant, nulligravid severe combined immunodeficient (SCID) mice. Endometriotic cells collected from patients with endometriosis were implanted subcutaneously in 30 SCID mice. These mice were randomized into two study groups: in the first group, mice were administered melatonin (20 mg/kg/day) following induction of endometriosis for four weeks; in the second group, nothing was administered. All the mice were given a high dose of exogenous estradiol (50 μg/kg/d, twice weekly). Four weeks after inoculation, necropsies were performed and endometriotic lesions were collected. All the lesions were evaluated histopathologically and the levels of SOD and MDA were assessed in the lesions. Results: Successful implantation was observed in the 28 mice that survived. Mean MDA level was 5.0±1.7 and 8.8±2.6 in the melatonin and control groups, respectively (p = 0.01); mean SOD level was 1.1 ± 0.1 and 1.0 ± 0.1 in the melatonin and control groups, respectively (p = 0.49). Mean histopathological score was lower in the melatonin group (p = 0.04). Conclusions: Melatonin was effective in the treatment of experimental endometriosis induced in SCID mice.

Keywords

- Benning ovarian cystic teratoma - 2D/3D/4D HDLive

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Condition tags

mesh:D004715endometriosis

MeSH descriptors

Endometriosis Melatonin Pregnancy, Animal Animals Antioxidants Antioxidants Disease Models, Animal Endometriosis Endometriosis Endometriosis Estradiol Estradiol Female Melatonin Mice Mice, SCID Pregnancy Prospective Studies Turkey

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