Ovarian endometrioid adenocarcinoma arising from an endometriotic cyst in a postmenopausal woman under tamoxifen therapy for breast cancer: a case report

Okugawa K, Kaoru Okugawa, Hirakawa T, Toshio Hirakawa, Ogawa S, Shinji Ogawa, Kaku T, Tsunehisa Kaku, Hitoo Nakano, Nakano H
Gynecologic Oncology · 2002 · vol. 87(2) , pp. 231–234 · doi:10.1006/gyno.2002.6824 · PMID:12477460 · W2034715909
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This case report describes ovarian endometrioid adenocarcinoma originating in an endometriotic cyst of a postmenopausal woman undergoing tamoxifen treatment for breast cancer.

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Abstract

BACKGROUND: Ovarian cancer arising from an endometriotic cyst in a postmenopausal woman under tamoxifen therapy is rare. CASE: We herein report the case of a 67-year-old woman with a history of breast cancer, taking tamoxifen citrate 20 mg/day for 4 years, who underwent an operation for left ovarian tumor. The postoperative histological diagnosis was endometrioid adenocarcinoma in an endometriotic cyst with a gradual transition of the degree of cellular atypia noted from typical endometriotic epithelium, to atypical endometriosis, and finally to adenocarcinoma. CONCLUSION: Tamoxifen may cause malignant transformation of endometriosis through atypical endometriosis even in the postmenopausal state. Atypical endometriosis may act as a precancerous lesion in the process of tamoxifen-induced malignant transformation of endometriosis.

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Condition tags

endometriosis

MeSH descriptors

Antineoplastic Agents, Hormonal Breast Neoplasms Carcinoma, Endometrioid Neoplasms, Second Primary Ovarian Cysts Ovarian Neoplasms Tamoxifen Aged Aged Antineoplastic Agents, Hormonal Antineoplastic Agents, Hormonal Antineoplastic Agents, Hormonal Breast Neoplasms Breast Neoplasms Carcinoma, Endometrioid Carcinoma, Endometrioid Carcinoma, Endometrioid Carcinoma, Endometrioid Cell Transformation, Neoplastic Cell Transformation, Neoplastic

Citation neighborhood (2-hop)

Papers in the corpus that this work cites (lower rings, blue) and that cite this one (upper rings, green). Dot size scales with the paper's in-corpus citation count — bigger dot = more influential within the endo/adeno field. Click a dot to open that paper. Outer rings show 2-hop neighbours — papers reached through the immediate citers/citees. [ collapse to 1-hop ]

References (19)

Cited by (18)

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