Retrospective evaluation of tumor markers in ovarian mature cystic teratoma and ovarian endometrioma

Kataoka T, Taeko Kataoka, Watanabe Y, Yoh Watanabe, Hiroshi Hoshiai, Hoshiai H
Journal of Obstetrics and Gynaecology Research · 2012 · vol. 38(8) , pp. 1071–1076 · doi:10.1111/j.1447-0756.2011.01833.x · PMID:22568880 · W1574877816
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This study evaluated serum tumor markers CA125, CA19-9, and STN in ovarian endometrioma and mature cystic teratoma, finding CA125 and CA19-9 showed abnormal elevations and correlations with tumor characteristics, unlike STN.

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Abstract

AIM: The aim of this study was to evaluate the correlation between clinicopathological characteristics and serum levels of tumor markers in patients with ovarian endometrioma (OE) and ovarian mature cystic teratoma (MCT). MATERIAL AND METHODS: Values of CA125, CA19-9, and sialyl Tn antigen (STN) were retrospectively investigated in 321 patients with OE. CA125, CA19-9, STN, and squamous cell carcinoma antigen (SCC) were examined in 435 patients with MCT. RESULTS: Mean values of CA125, CA19-9, and STN were 105.3 U/mL, 58.0 U/mL, and 31.1 U/mL in OE, while the values were 26.8 U/mL, 246.8 U/mL, and 24.7 U/mL in MCT. Abnormal elevation of CA125, CA19-9, and STN was observed in 53.3%, 38.9, and 13.5 of OE, and in 12.9, 50.6, and 4.6% of MCT, respectively. CA125 level was significantly higher in bilaterally occurring OE and premenopausal patients with MCT, while the value of CA19-9 was significantly higher in cases of bilaterally occurring MCT. Furthermore, the levels of CA125 and CA19-9 showed significant correlations with tumor diameter, while the levels of STN and SCC showed no significant correlations with tumor diameter. The highest CA125 level (9513 U/mL) was observed in OE and the highest CA19-9 level (25 590 U/mL) was observed in MCT. CONCLUSION: Although abnormal increases in the levels of CA125 and CA19-9 were often observed, the levels of STN were not influenced by clinicopathologic factors in OE and MCT. Further studies of the clinical usefulness of STN for detecting malignant tumors in OE and MCT are needed.

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Condition tags

endometriosisendometrioma

MeSH descriptors

Biomarkers, Tumor Endometriosis Ovarian Neoplasms Teratoma Adolescent Adolescent Adult Adult Aged Aged Aged, 80 and over Aged, 80 and over Antigens, Neoplasm Antigens, Neoplasm Antigens, Neoplasm Biomarkers, Tumor Biomarkers, Tumor CA-125 Antigen CA-125 Antigen CA-125 Antigen

Citation neighborhood (2-hop)

Papers in the corpus that this work cites (lower rings, blue) and that cite this one (upper rings, green). Dot size scales with the paper's in-corpus citation count — bigger dot = more influential within the endo/adeno field. Click a dot to open that paper. Outer rings show 2-hop neighbours — papers reached through the immediate citers/citees. [ collapse to 1-hop ]

References (23)

Cited by (7)

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