MiR-195 inhibits proliferation and growth and induces apoptosis of endometrial stromal cells by targeting FKN

Wang Y, Yun Wang, Chen H, Hong Chen, Yonglun Fu, Fu Y, Ai A, Ai Ai, Songguo Xue, Xue S, Qifeng Lyu, Lyu Q, Yanping Kuang, Kuang Y
International journal of clinical and experimental pathology · 2013 · vol. 6(12) , pp. 2824–34 · PMID:24294368 · PMC3843262 · W2181255064
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MiR-195 inhibits proliferation and growth, and induces apoptosis in endometrial stromal cells by targeting Fractalkine (FKN).

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Abstract

MiR-195, which exhibits a proliferation-inhibiting role in different tumors, has been reported to be down-regulated in the ectopic endometrium. The aim of this study was to determine the impact of miR-195 on the biological characteristic of the endometrial stromal cells (ESCs). MiR-195 has been presumed to target the 3'-untranslated regions (3'-UTR) of Fractalkine (FKN), which also plays important roles in endometriosis. Fluorescence reporter assays showed that miR-195 effectively binds to the 3'-UTR of FKN. The normal ESCs showed a significant higher miR-195 expression than that of eutopic and ectopic ESCs associated with endometriosis, while the FKN expression showed opposite results. MiR-195 mimics inhibited proliferation and growth and induced apoptosis of eutopic ESCs, and these effects were abolished by FKN-siRNA. miR-195 could decrease the expression of survivin, matrix metalloproteinase-9 (MMP9) and up-regulate the expression of CD82, tissue inhibitor of metalloproteinase 1 (TIMP1) and TIMP2 of eutopic ESCs by targeting FKN. Our study has demonstrated for the first time that miR-195 plays important roles in regulating the functions of ESCs through targeting FKN. The information may be useful for developing a new therapeutic strategy for endometriosis.

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Condition tags

endometriosis

MeSH descriptors

Apoptosis Apoptosis Cell Proliferation Cell Proliferation Chemokine CX3CL1 Endometriosis Endometrium MicroRNAs Stromal Cells 3' Untranslated Regions 3' Untranslated Regions Adult Adult Binding Sites Binding Sites Case-Control Studies Case-Control Studies Cells, Cultured Cells, Cultured Cell Survival

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