Usefulness of hemostatic sealants for minimizing ovarian damage during laparoscopic cystectomy for endometriosis

Chahien Choi, Choi C, Woo Young Kim, Lee DH, Dong Hee Lee, San Hui Lee, Lee SH
Journal of Obstetrics and Gynaecology Research · 2017 · vol. 44(3) , pp. 532–539 · doi:10.1111/jog.13542 · PMID:29271052 · W2777621177
RCT OA: closed CC0 ⤵ 25 in-corpus citations
View on OpenAlex View on PubMed View at publisher
⚙ AI-generated summary by gemini-2.5-flash-lite, 2026-06-06 ⓘ

This study found that hemostatic sealants preserved ovarian reserve better than bipolar coagulation, as shown by a smaller decrease in anti-Müllerian hormone levels three months after laparoscopic endometriotic cystectomy.

One-sentence paraphrase of the abstract; not a substitute for reading it. No clinical advice. How this works

Abstract

AIM: We aimed to evaluate the impact of topical hemostatic sealants and bipolar coagulation during laparoscopic ovarian endometriotic cyst resection on ovarian reserve by comparing the rates of decrease in anti-Müllerian hormone (AMH). METHODS: A randomized prospective data collection was made on women aged 19-45 years who planned to have laparoscopic ovarian cystectomy at one of two institutions (n = 80), Kangbuk Samsung Hospital, Seoul, Korea or National Health Insurance Service Ilsan Hospital, Goyang, Korea, from January 2014 to April 2016. Patients were randomly divided into two groups treated with either a topical hemostatic sealant or bipolar coagulation for hemostasis. The hemostatic group was randomized to the FloSeal or TachoSil subgroups. Preoperative and 3-month postoperative AMH levels were checked and the rates of decrease of AMH were compared. All patients enrolled were treated with dienogest (Visanne) for 6-12 months. None were lost to follow-up at postoperative 3 months, but about one-third of the patients had been lost to follow-up by 6-12 months. RESULTS: AMH was significantly decreased in both groups 3 months postoperatively; however, the rate of decrease in the bipolar coagulation group was greater than that in the hemostatic sealant group, 41.9% (interquartile range [IQR], 22.29-65.24) versus 18.1% (IQR, 10.94-29.90), P = 0.007. Between the two hemostatic subgroups, there was no significant difference in AMH decrease rate, 14.95% (IQR, 11.34-21.21) versus 18.1% (IQR 9.76-40.70), P = 0.204. CONCLUSION: Hemostatic sealants may be an alternative to bipolar coagulation for preservation of ovarian reserve after laparoscopic ovarian cystectomy for endometriosis.

My notes (saved in your browser only)

Condition tags

endometriosis

MeSH descriptors

Anti-Mullerian Hormone Endometriosis Gynecologic Surgical Procedures Hemostasis, Surgical Hemostatics Hemostatic Techniques Hemostatic Techniques Laparoscopy Outcome Assessment, Health Care Outcome Assessment, Health Care Ovarian Cysts Ovarian Reserve Ovarian Reserve Adult Adult Anti-Mullerian Hormone Anti-Mullerian Hormone Endometriosis Endometriosis Female

Citation neighborhood (2-hop)

Papers in the corpus that this work cites (lower rings, blue) and that cite this one (upper rings, green). Dot size scales with the paper's in-corpus citation count — bigger dot = more influential within the endo/adeno field. Click a dot to open that paper. Outer rings show 2-hop neighbours — papers reached through the immediate citers/citees. [ collapse to 1-hop ]

References (30)

Cited by (25)

Source provenance

europepmc
last seen: 2026-10-14T06:08:39.101224+00:00
openalex
last seen: 2026-06-04T00:00:01.174412+00:00
pubmed
last seen: 2026-10-08T21:21:08.819620+00:00
unpaywall
last seen: 2026-10-13T06:25:51.201866+00:00
License: CC0 · commercial use OK