Phospholipase C activity in human endometrium: its significance in endometrial pathology

R. C. Bonney, S Franks, Stephen Franks
Clinical endocrinology · 1987 · vol. 27(3) , pp. 307–320 · doi:10.1111/j.1365-2265.1987.tb01157.x · PMID:3427790 · W2050965755
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Endometrial phospholipase C activity, which is calcium-dependent and pH 5.5 optimal, was found to be significantly elevated in women with menorrhagia and other gynecological disorders, suggesting a potential role in associated pathologies.

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Abstract

Phospholipase C activity was measured in human endometrium using an assay based on the release of total labelled water soluble products (inositol, inositol phosphates) from L-3-phosphatidyl-[2-3H] inositol. The enzyme was shown to be calcium dependent and to have an optimum pH of 5.5. There was no difference between proliferative phase and secretory phase endometrium with respect to phospholipase C activity either in women with normal menstrual blood loss (proliferative phase: 3.7 +/- 0.7 (mean +/- SD), secretory phase: 4.5 +/- 2.0 nmol/mg protein/min) or in those complaining of severe menorrhagia (proliferative phase: 5.8 +/- 2.8, secretory phase: 7.0 +/- 2.8 nmol/mg protein/min). However, women complaining of severe menorrhagia had significantly higher endometrial phospholipase C activity than those in the normal group (P less than 0.01 and P less than 0.02 for proliferative and secretory phases respectively). Endometrial phospholipase C activity was also elevated in the presence of other gynaecological disorders, e.g. dysmenorrhoea, adenocarcinoma of the cervix and endometrial hyperplasia. The results indicate that phospholipase C activity in human endometrium is not related to the stage of the menstrual cycle but that in the presence of menorrhagia and other gynaecological disorders, activity is increased. Phospholipase C could be implicated in the generation of arachidonic acid for prostaglandin synthesis which may in turn be associated with these abnormalities.

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Condition tags

dysmenorrhea

MeSH descriptors

Endometrium Type C Phospholipases Uterine Diseases Adult Endometrium Female Humans Menorrhagia Menorrhagia Menstrual Cycle Middle Aged Type C Phospholipases Uterine Diseases

Citation neighborhood (2-hop)

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References (23)

Cited by (8)

SciLite annotations

organisms 4
human human noordeloos 2009062 human
chemicals 8
water inositol inositol phosphate phosphatidylinositol inositol calcium arachidonic acid prostaglandin

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