The effect of danazol in sexual precocity

The Johns Hopkins medical journal · 1975 · vol. 137(6) , pp. 265–9 · PMID:173912 · W2418027294
Other OA: closed CC0 ⤵ 17 in-corpus citations
View on OpenAlex View on PubMed
⚙ AI-generated summary by gemini-2.5-flash-lite, 2026-06-08 ⓘ

Danazol treatment halted sexual development progression in prepubertal children and suppressed sex hormones, but did not fully suppress the pituitary-gonadal axis or consistently affect growth and maturation.

One-sentence paraphrase of the abstract; not a substitute for reading it. No clinical advice. How this works

Abstract

The effect of Danazol, a synthetic 2,3 isoxazol derivative of 17 alpha-ethinyl testosterone, was assessed in three girls and two boys with sexual precocity. Progression of sexual development ceased during administration of Danazol; the effect upon growth rate and skeletal maturation was equivocal. Serum estrogen and progesterone concentrations in the girls were lower during treatment; serum testosterone and dehydroepiandrosterone levels in the boys were also lower. Serum and urinary luteinizing hormone concentrations were inconsistently suppressed. No effect upon follicle-stimulating hormone levels could be demonstrated. Although Danazol appears to inhibit sexual development, this study indicates that the pituitary-gonadal axis is not completely suppressed. Growth rate is not reverted to normal, and virilization may occur among girls. Because undesirable side effects may outweight desirable results, careful consideration is recommended before Danazol is prescribed in the management of sexual precocity.

My notes (saved in your browser only)

MeSH descriptors

Danazol Pregnadienes Puberty, Precocious 17-Ketosteroids 17-Ketosteroids Age Determination by Skeleton Androgens Androgens Body Height Body Weight Bone Development Child Child, Preschool Danazol Estrogens Estrogens Female Gonadotropins Gonadotropins Growth

Citation neighborhood (2-hop)

Papers in the corpus that this work cites (lower rings, blue) and that cite this one (upper rings, green). Dot size scales with the paper's in-corpus citation count — bigger dot = more influential within the endo/adeno field. Click a dot to open that paper. Outer rings show 2-hop neighbours — papers reached through the immediate citers/citees. [ collapse to 1-hop ]

Cited by (16)

Source provenance

openalex
last seen: 2026-05-10T10:24:24.530068+00:00
pubmed
last seen: 2026-10-08T21:04:17.981133+00:00
License: CC0 · commercial use OK