Transient adrenogenital syndrome due to exposure to danazol in utero

M Castro-Magana, Mariano Castro-Magaña, T Cheruvanky, P J Collipp, Z Ghavami-Maibodi, M Angulo, C Stewart
American journal of diseases of children (1960) · 1981 · vol. 135(11) , pp. 1032 · doi:10.1001/archpedi.1981.02130350036012 · PMID:6271010 · W1988320682
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This case report details a premature female infant exposed to danazol in utero who exhibited transient virilization and laboratory findings consistent with a partial 21-hydroxylation block and a possible 11 beta-monooxygenase block, which resolved within a year.

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Abstract

We describe a premature female infant exposed in utero to danazol during the first trimester of pregnancy. She was first observed in the newborn period with marked degree virilization and clinical findings suggestive of salt-losing congenital adrenal hyperplasia. This was supported by the high plasma levels of 17 alpha-hydroxyprogesterone and adrenocorticotropic hormone and low plasma cortisol level. Levels of testosterone, androstenedione, 11-deoxycortisol, and renin were also elevated. An excessive increase in the levels of 17 alpha-hydroxyprogesterone and 11-deoxycortisol to corticotropin administration associated with impaired increase in plasma cortisol level strongly suggests a partial block in the 21-hydroxylation of 17 alpha-hydroxyprogesterone. However, the high levels of 11-deoxycortisol also suggest a block of the steroid 11 beta-monooxygenase. A year later she was found to have normal basal levels of the adrenal steroids and normal response to corticotropin administration, pointing out the transitory nature of these abnormalities. It may be hypothesized that danazol produced a transitory block of the steroid 21- and 11 beta-monooxygenases in this child.

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MeSH descriptors

Adrenal Hyperplasia, Congenital Danazol Infant, Premature, Diseases Pregnadienes Adrenal Hyperplasia, Congenital Adrenal Hyperplasia, Congenital Adrenocorticotropic Hormone Adrenocorticotropic Hormone Androstenedione Androstenedione Cortodoxone Cortodoxone Cosyntropin Danazol Female Humans Hydrocortisone Hydrocortisone Hydroxyprogesterones Hydroxyprogesterones

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