Implication of the RAGE-EN-RAGE axis in endometriosis

Indu Sharma, Veena Dhawan, Dhawan V, Saha SC, Subhash Chand Saha, Bagga Rashmi, Rashmi B, Lakhbir Kaur Dhaliwal, Lakhbir Dhaliwal, Dhaliwal LK
International Journal of Gynecology & Obstetrics · 2010 · vol. 110(3) , pp. 199–202 · doi:10.1016/j.ijgo.2010.03.037 · PMID:20537326 · W2023761269
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This study found significantly increased mRNA and protein expression of COX-2, RAGE, and EN-RAGE in endometriotic cells compared to control cells.

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Abstract

OBJECTIVE: To investigate the involvement of the receptor gene for advanced glycation (RAGE), its ligand EN-RAGE, and COX-2 in endometriosis. METHODS: The mRNA and protein expression of the corresponding genes were determined from endometriotic cells from 28 study patients and healthy endometrial stromal cells from 20 controls by semiquantitative RT-PCR and Western blot analysis, respectively, using beta-actin as an invariant control. RESULTS: The expression of COX-2, RAGE, and EN-RAGE was significantly increased, as evidenced by the significantly greater mRNA and protein expression in the cells of the study patients (P<0.001). Previous treatment for endometriosis did not lessen mRNA and protein expression (P<0.001). CONCLUSION: Our findings strengthen the hypothesis of an underlying inflammation in the pathophysiology of endometriosis and suggest exploring anti-inflammatory therapies as adjunct treatment.

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Condition tags

endometriosis

MeSH descriptors

Cyclooxygenase 2 Endometriosis Endometrium Receptors, Immunologic S100 Proteins Adult Adult Case-Control Studies Case-Control Studies Cyclooxygenase 2 Cyclooxygenase 2 Cyclooxygenase 2 Endometriosis Endometriosis Endometrium Endometrium Endometrium Female Female Gene Expression

Citation neighborhood (2-hop)

Papers in the corpus that this work cites (lower rings, blue) and that cite this one (upper rings, green). Dot size scales with the paper's in-corpus citation count — bigger dot = more influential within the endo/adeno field. Click a dot to open that paper. Outer rings show 2-hop neighbours — papers reached through the immediate citers/citees. [ collapse to 1-hop ]

References (24)

Cited by (8)

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