Implication of the RAGE–EN‐RAGE axis in endometriosis

Indu Sharma, Veena Dhawan, Subhash Chand Saha, Bagga Rashmi, Lakhbir Dhaliwal, Lakhbir Kaur Dhaliwal
International Journal of Gynecology & Obstetrics · 2010 · vol. 110(3) , pp. 199–202 · doi:10.1016/j.ijgo.2010.03.037 · PMID:20537326 · W2023761269
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Abstract

OBJECTIVE: To investigate the involvement of the receptor gene for advanced glycation (RAGE), its ligand EN-RAGE, and COX-2 in endometriosis. METHODS: The mRNA and protein expression of the corresponding genes were determined from endometriotic cells from 28 study patients and healthy endometrial stromal cells from 20 controls by semiquantitative RT-PCR and Western blot analysis, respectively, using beta-actin as an invariant control. RESULTS: The expression of COX-2, RAGE, and EN-RAGE was significantly increased, as evidenced by the significantly greater mRNA and protein expression in the cells of the study patients (P<0.001). Previous treatment for endometriosis did not lessen mRNA and protein expression (P<0.001). CONCLUSION: Our findings strengthen the hypothesis of an underlying inflammation in the pathophysiology of endometriosis and suggest exploring anti-inflammatory therapies as adjunct treatment.

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Condition tags

mesh:D004715endometriosis

MeSH descriptors

Cyclooxygenase 2 Endometriosis Endometrium Receptors, Immunologic S100 Proteins Adult Case-Control Studies Cyclooxygenase 2 Cyclooxygenase 2 Endometriosis Endometrium Endometrium Female Gene Expression Humans Receptor for Advanced Glycation End Products Receptors, Immunologic Receptors, Immunologic S100A12 Protein S100 Proteins

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