A comparative study of ovarian and pelvic wall-infiltrating endometriosis

Khare VK, Vivek Khare, V K Khare, Dan C. Martin, D C Martin, M Eltorky, Mahmoud Eltorky, Eltorky M
The Journal of the American Association of Gynecologic Laparoscopists · 1996 · vol. 3(2) , pp. 235–239 · doi:10.1016/s1074-3804(96)80006-5 · PMID:9050632 · W2024037956
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This comparative study investigated ovarian and pelvic wall-infiltrating endometriosis, analyzing differences in their presentation and characteristics.

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Abstract

STUDY OBJECTIVE: To compare the histology of ovarian endometriomas (OE) with that of pelvic wall-infiltrating endometriosis (PWIE) in an attempt to elucidate their histopathologic and clinical differences. DESIGN: Retrospective histologic study. SETTING: University-affiliated hospital. SUBJECTS: Randomly selected tissue samples of 10 cases each of OE and PWIE. Interventions. Immunoperoxidase and Masson's trichrome stains were applied to the samples to determine the presence of myofibroblasts and collagen, respectively. MEASUREMENTS AND MAIN RESULTS: All cases of OE showed changes suggestive of type 3 collagen deposition and myofibroblast proliferation. All cases of PWIE showed changes suggestive of type 1 collagen deposition and extensive smooth muscle metaplasia. The endometrial glands and stroma of OE tended to be on the inside lining of the chocolate cyst and did not freely intermix with native ovarian collagen. The lesions of PWIE, however, showed endometrial glands and stroma mixing freely with the native pelvic wall collagen. CONCLUSIONS: These findings suggest two different mechanisms for the pathogenesis of OE and PWIE and offer a rationale for using different surgical approaches to the different sites. Ovarian endometriosis is a lesion within the ovary with a response compatible with recent metastasis, whereas PWIE appears to be a metaplastic reaction.

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Condition tags

endometriosis

MeSH descriptors

Endometriosis Ovarian Diseases Coloring Agents Coloring Agents Endometriosis Endometriosis Female Female Humans Humans Immunoenzyme Techniques Immunoenzyme Techniques Metaplasia Metaplasia Muscle, Smooth Muscle, Smooth Muscle, Smooth Ovarian Diseases Ovarian Diseases Retrospective Studies

Citation neighborhood (2-hop)

Papers in the corpus that this work cites (lower rings, blue) and that cite this one (upper rings, green). Dot size scales with the paper's in-corpus citation count — bigger dot = more influential within the endo/adeno field. Click a dot to open that paper. Outer rings show 2-hop neighbours — papers reached through the immediate citers/citees. [ collapse to 1-hop ]

References (21)

Cited by (29)

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