Müllerian adenosarcoma arising in a subserosal adenomyoma

Elshafie M, Mona Elshafie, Siavash Rahimi, Raji Ganesan, Ganesan R, Lynn Hirschowitz, Hirschowitz L
International journal of surgical pathology · 2012 · vol. 21(2) , pp. 186–189 · doi:10.1177/1066896912453852 · PMID:22820101 · W2006745388
Case report OA: closed CC0 ⤵ 4 in-corpus citations
View on OpenAlex View on PubMed View at publisher
⚙ AI-generated summary by gemini-2.5-flash-lite, 2026-06-12 ⓘ

This paper reports a rare case of low-grade Müllerian adenosarcoma arising from a subserosal adenomyoma in a 46-year-old woman, highlighting the importance of recognizing this origin to avoid overstaging and inappropriate adjuvant treatment.

One-sentence paraphrase of the abstract; not a substitute for reading it. No clinical advice. How this works

Abstract

Müllerian adenosarcomas most commonly arise in the uterine corpus from the eutopic endometrium. Occasionally, they arise in the cervix, vagina, broad and round ligaments, and ovaries and rarely in extragenital sites, usually in association with endometriosis. The authors report a rare case of extraendometrial, intramural adenosarcoma of low grade arising from a subserosal adenomyoma in a 46-year-old woman who presented with vaginal bleeding. No evidence of eutopic endometrial origin was identified; the adenosarcoma showed only limited myometrial invasion and no serosal involvement. Because of its subserosal location, the tumor would be overstaged as IC (deeply myoinvasive) in the new FIGO staging system. Stage IC tumors would normally be considered for adjuvant treatment, which would be inappropriate in this case. To avoid overstaging and inappropriate treatment, it is important to recognize that adenosarcoma can, rarely, arise in adenomyomas (or adenomyosis).

My notes (saved in your browser only)

Condition tags

endometriosisadenomyosis

MeSH descriptors

Adenomyoma Adenosarcoma Neoplasms, Multiple Primary Uterine Neoplasms Adenomyoma Adenomyoma Adenosarcoma Adenosarcoma Female Female Humans Humans Middle Aged Middle Aged Neoplasms, Multiple Primary Neoplasms, Multiple Primary Uterine Neoplasms Uterine Neoplasms

Citation neighborhood (2-hop)

Papers in the corpus that this work cites (lower rings, blue) and that cite this one (upper rings, green). Dot size scales with the paper's in-corpus citation count — bigger dot = more influential within the endo/adeno field. Click a dot to open that paper. Outer rings show 2-hop neighbours — papers reached through the immediate citers/citees. [ collapse to 1-hop ]

References (16)

Cited by (4)

Source provenance

europepmc
last seen: 2026-10-23T06:08:06.940705+00:00
openalex
last seen: 2026-06-04T00:00:01.174412+00:00
pubmed
last seen: 2026-10-08T21:10:37.302907+00:00
unpaywall
last seen: 2026-10-23T06:24:35.503409+00:00
License: CC0 · commercial use OK