A mixture of St. John's wort and sea buckthorn oils regresses endometriotic implants and affects the levels of inflammatory mediators in peritoneal fluid of the rat: A surgically induced endometriosis model

Mert İlhan, İpek Süntar, Mürşide Ayşe Demirel, Demirel MA, Mürşide Ayşe Demırel, Yeşilada E, Erdem Yeşilada, Keleş H, Hikmet Keleş, Küpeli Akkol E, Esra Küpeli Akkol
Taiwanese journal of obstetrics & gynecology · 2016 · vol. 55(6) , pp. 786–790 · doi:10.1016/j.tjog.2015.01.006 · PMID:28040120 · W2564626363
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A mixture of sea buckthorn and St. John's wort oils reduced endometriotic implant size and intra-abdominal adhesions in rats, while decreasing inflammatory mediators in peritoneal fluid.

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Abstract

OBJECTIVE: Sea buckthorn (Hippophae rhamnoides L.) and St. John's wort (Hypericum perforatum L.) are used as an emmenagog and for the treatment of other gynecological disorders including uterus inflammation and endometriosis. The aim of the present study is to investigate the potential of a mixture of sea buckthorn and St. John's wort oils (HrHp oil) in the treatment of endometriosis. MATERIALS AND METHODS: The activity was assessed in surgically induced endometriosis in rats. A 15-mm piece of endometrium was sutured into the abdominal wall. Twenty-eight days later, a second laparotomy was performed to calculate the endometrial foci areas and to score intra-abdominal adhesions. The rats were treated with either vehicle, HrHp oil formulation, or the reference (buserelin acetate). At the end of the experiment all rats were sacrificed and endometriotic foci areas and intra-abdominal adhesions were re-evaluated. The tissue sections were analyzed histopathologically. Peritoneal fluids of the experimental animals were collected in order to detect the levels of tumor necrosis factor-α, vascular endothelial growth factor, and interleukin-6, which might be involved in the etiology of endometriosis. RESULTS: In the HrHp oil-treated group, the volumes of endometriotic implants were found to be significantly decreased (from 50.8 mm3 to 18.6 mm3, p<0.001) without any adhesion (0.0±0.0, p<0.001) when compared to the control group (3.1±0.9). The levels of tumor necrosis factor-α decreased from 7.02±1.33 pg/mL to 4.78±1.02 pg/mL (p<0.01); vascular endothelial growth factor from 17.39±8.52 pg/mL to 9.67±5.04 pg/mL (p<0.01); and interleukin-6 from 50.95±22.84 pg/mL to 29.11±7.45 pg/mL (p<0.01), respectively, after HrHp oil treatment. CONCLUSION: HrHp oil may be a promising alternative for the treatment of endometriosis.

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Condition tags

endometriosis

MeSH descriptors

Endometriosis Endometrium Hippophae Hippophae Hypericum Hypericum Plant Extracts Plant Oils Animals Animals Complementary Therapies Complementary Therapies Disease Models, Animal Disease Models, Animal Drug Combinations Drug Combinations Endometriosis Endometriosis Endometriosis Endometriosis

Citation neighborhood (2-hop)

Papers in the corpus that this work cites (lower rings, blue) and that cite this one (upper rings, green). Dot size scales with the paper's in-corpus citation count — bigger dot = more influential within the endo/adeno field. Click a dot to open that paper. Outer rings show 2-hop neighbours — papers reached through the immediate citers/citees. [ collapse to 1-hop ]

References (28)

Cited by (9)

SciLite annotations

organisms 10
sea-buckthorn zitter rats sea-buckthorn actinobacterium l hypericum perforatum sea-buckthorn rattus sp. rattus sp. rattus sp. multicellular animals
chemicals 2
buserelin acetate

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