Association of the interferon-γ gene (CA)n repeat polymorphism with endometriosis

J. J. Kim, Kim JJ, Y. M. Choi, Choi YM, Hwang SS, S S Hwang, SS Hwang, Yoon SH, S H Yoon, Lee GH, G H Lee, S J Chae, Soo Jin Chae, KR Hwang, K R Hwang, Hwang KR, Moon SY, S Y Moon
BJOG: An International Journal of Obstetrics & Gynaecology · 2011 · vol. 118(9) , pp. 1061–1066 · doi:10.1111/j.1471-0528.2011.02963.x · PMID:21477169 · W1566754997
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This case-control study investigated the interferon-γ (IFN-γ) gene (CA)n repeat polymorphism, finding that genotypes with fewer repeats (12-13) were significantly more common in women with endometriosis.

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Abstract

OBJECTIVE: To investigate whether the interferon-γ (IFN-γ) gene (CA)(n) repeat polymorphism is associated with susceptibility to endometriosis. DESIGN: Case-control study. SETTING: University Department of Obstetrics and Gynaecology. POPULATION: Women with (n = 622) and without (n = 442) endometriosis. METHODS: Genotyping was performed by fluorescent polymerase chain reaction (PCR) and gene-scan analysis. MAIN OUTCOME MEASURES: Genotype distribution and allele frequency of the dinucleotide (CA)(n) repeat polymorphism in the IFN-γ gene. RESULTS: Seven alleles (12-18 repeats) of the IFN-γ gene (CA)(n) repeat polymorphism were found. In both patients with endometriosis and controls the most common allele was composed of 13 repeats, followed by an allele of 15 repeats, and then by an allele of 12 repeats. Patients with endometriosis had a significantly higher incidence of genotypes with alleles composed of fewer repeats (12-13 repeats), compared with the controls (92.0 versus 84.4%, respectively, P < 001). CONCLUSIONS: Our results suggest that the (CA)(n) repeat polymorphism in the IFN-γ gene may be associated with a risk of endometriosis in the South Korean population.

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Condition tags

endometriosis

MeSH descriptors

Endometriosis Gene Frequency Gene Frequency Genetic Predisposition to Disease Genetic Predisposition to Disease Interferon-gamma Trinucleotide Repeats Adult Adult Case-Control Studies Case-Control Studies Endometriosis Endometriosis Female Female Genotype Genotype Humans Humans Interferon-gamma

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Papers in the corpus that this work cites (lower rings, blue) and that cite this one (upper rings, green). Dot size scales with the paper's in-corpus citation count — bigger dot = more influential within the endo/adeno field. Click a dot to open that paper. Outer rings show 2-hop neighbours — papers reached through the immediate citers/citees. [ collapse to 1-hop ]

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