Leukotriene release by endometrium and myometrium throughout the menstrual cycle in dysmenorrhoea and menorrhagia
Other
OA: closed
CC0
⤵ 35 in-corpus citations
AI-generated summary
Endometrial leukotriene release, highest during menstruation, was significantly greater than myometrial release and elevated in women with dysmenorrhea but not correlated with menstrual blood loss.
One-sentence paraphrase of the abstract; not a substitute for reading it. No clinical advice. How this works
Abstract
Endometrium and myometrium were collected at hysterectomy from 21 women with measured menstrual blood loss. Eight women complained of dysmenorrhea and the remaining 13 had pain-free periods. Specimens were obtained throughout the menstrual cycle (menstrual, n = 5; follicular, n = 4; early luteal, n = 3; mid-luteal, n = 5; late luteal, n = 4). Leukotriene C4, leukotriene D4 and leukotriene E4 release were examined using a short-term incubation technique. Endometrial leukotriene release, which was always significantly greater than myometrial release, changed throughout the menstrual cycle and the highest concentrations were found during menstruation. Endometrial, but not myometrial, leukotriene concentrations were significantly higher in tissues obtained from women with a complaint of dysmenorrhoea compared with those in tissue from pain-free women. No correlation was found between leukotriene release in either endometrium or myometrium and menstrual blood loss (range 15-457 ml).
My notes (saved in your browser only)
Condition tags
MeSH descriptors
Citation neighborhood (2-hop)
Papers in the corpus that this work cites (lower rings, blue) and that cite this one (upper rings, green). Dot size scales with the paper's in-corpus citation count — bigger dot = more influential within the endo/adeno field. Click a dot to open that paper. Outer rings show 2-hop neighbours — papers reached through the immediate citers/citees. [ collapse to 1-hop ]
Cited by (33)
- Investigational drugs for the treatment of dysmenorrhea 2024
- Primary Dysmenorrhea: pathophysiology 2021
- Blutungsstörungen, Dysmenorrhö und Endometriose im Jugendalter 2021
- Common and specific gene signatures among three different endometriosis subtypes 2020
- Non-steroidal anti-inflammatory drugs for heavy menstrual bleeding 2019
- Polycystic ovarian morphology is associated with primary dysmenorrhea in young Korean women 2019
- Interventions for the treatment of heavy menstrual bleeding 2018
- Menstrual pain and risk of epithelial ovarian cancer: Results from the Ovarian Cancer Association Consortium 2017
- Is montelukast effective in regression of endometrial implants in an experimentally induced endometriosis model in rats? 2014
- Menstrual pain and epithelial ovarian cancer risk 2014
- Non-steroidal anti-inflammatory drugs for heavy menstrual bleeding 2013
- Studying the Effect of Montelukast in the Treatment of Dysmenorrhea: A single-Blind, Placebo-controlled Trial 2012
- Dysmenorrhea in adolescents and young adults: an update on pharmacological treatments and management strategies 2012
- Efficacy of montelukast, a leukotriene receptor antagonist, for the treatment of dysmenorrhea: a prospective, double-blind, randomized, placebo-controlled study 2009
- Dysmenorrhea in adolescents and young adults: from pathophysiology to pharmacological treatments and management strategies 2008
- The Management of Chronic Pelvic Pain 2008
- Nonsteroidal anti-inflammatory drugs for heavy menstrual bleeding 2007
- Dysmenorrhea in adolescents and young adults: etiology and management 2006
- Benefits and risks of pharmacological agents used for the treatment of menorrhagia 2004
- A Contemporary Approach to Dysmenorrhea in Adolescents 2002
- A contemporary approach to dysmenorrhea in adolescents 2002
- Leukotrienes in gynaecology: the hypothetical value of anti-leukotriene therapy in dysmenorrhoea and endometriosis 2000
- Nonsteroidal anti-inflammatory drugs for heavy menstrual bleeding 1998
- Does endometrial resection help dysmenorrhea? 1997
- Production of 12-hydroxyeicosatetraenoic acid in early pregnant uterine cervix--lack of correlation to mifepristone-induced cervical ripening. A double-blind randomized biomechanical and biochemical study 1992
- Prostaglandins in Dysmenorrhoea and Endometriosis 1992
- Effects of piriprost (U-60, 257B) and leukotrienes on alkaline phosphatase activity of rat endometrial stromal cells in vitro 1991
- Examination of the effects of piriprost (U-60,257B) on alkaline phosphatase activity of rat endometrial stromal cells in vitro 1991
- Human menstruation and eicosanoids 1990
- Menstrual disorders--an overview 1989
- Eicosanoids in primary dysmenorrhea, endometriosis and menstrual migraine 1989
- Dysfunctional uterine bleeding 1989
- Topographical distribution of prostaglandin E receptors in human myometrium 1988
Source provenance
- openalex
- last seen: 2026-06-10T17:14:06.276822+00:00
- pubmed
- last seen: 2026-10-08T21:23:18.497579+00:00
- unpaywall
- last seen: 2026-10-13T06:25:51.201866+00:00
License: CC0
· commercial use OK