Effects of LNG-IUS on nerve growth factor and its receptors expression in patients with adenomyosis

Young Sik Choi, SiHyun Cho, Kyung Jin Lim, Lim KJ, Young Eun Jeon, Jeon YE, Hyo In Yang, Yang HI, Kyung Eun Lee, Lee KE, Kamdar Heena, Heena K, Seok Kyo Seo, Hye Yeon Kim, Kim HY, Byung Seok Lee, Lee BS
Growth factors (Chur, Switzerland) · 2010 · vol. 28(6) , pp. 452–460 · doi:10.3109/08977194.2010.511619 · PMID:20854189 · W2077836399
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This study found that the levonorgestrel-releasing intrauterine system (LNG-IUS) significantly decreased expression of nerve growth factor (NGF), NGFR p75, and TrkA in endometrial and myometrial tissues of adenomyosis patients compared to untreated patients.

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Abstract

The levonorgestrel-releasing intrauterine system (LNG-IUS) is effective in the treatment of dysmenorrhea associated with adenomyosis. However, the mechanism of pain relief of LNG-IUS in patients with adenomyosis is unclear. We aimed to investigate the effects of LNG-IUS on the expression of nerve growth factor (NGF) and its receptors, NGFR p75 and TrkA in patients with adenomyosis. Endometrial and myometrial tissues were prepared from 17 LNG-IUS-treated patients and 15 hormonally untreated patients who had undergone hysterectomies for adenomyosis. Immunohistochemistry with antibodies against NGF, NGFR p75, and TrkA, was performed. The expression of NGF, NGFR p75, and TrkA in endometrium and myometrium of LNG-IUS-treated patients was significantly decreased compared to those of hormonally untreated patients. Our findings may indicate that the suppression of NGF and its receptors by LNG-IUS is another possible mechanism of relieving pain in patients with adenomyosis.

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Condition tags

dysmenorrheaendometriosisadenomyosis

MeSH descriptors

Endometriosis Levonorgestrel Nerve Growth Factor Receptors, Nerve Growth Factor Adult Adult Dysmenorrhea Dysmenorrhea Dysmenorrhea Endometriosis Endometriosis Endometriosis Female Female Fluorescent Antibody Technique Fluorescent Antibody Technique Humans Humans Levonorgestrel Levonorgestrel

Citation neighborhood (2-hop)

Papers in the corpus that this work cites (lower rings, blue) and that cite this one (upper rings, green). Dot size scales with the paper's in-corpus citation count — bigger dot = more influential within the endo/adeno field. Click a dot to open that paper. Outer rings show 2-hop neighbours — papers reached through the immediate citers/citees. [ collapse to 1-hop ]

References (27)

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