Predictive factors for spontaneous conception in women with moderate and severe endometriosis following operative laparoscopy: A cohort study

Nivedita Gupta, Gupta N, Joseph T, Treasa Joseph, Reka Karuppusami, Karuppusami R, Kunjummen AT, Aleyamma T Kunjummen, Mohan S. Kamath, Kamath MS
European journal of obstetrics, gynecology, and reproductive biology · 2025 · vol. 309 , pp. 192–199 · doi:10.1016/j.ejogrb.2025.03.052 · PMID:40168751 · W4408926023
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This cohort study identified predictive factors for spontaneous conception in women with moderate and severe endometriosis after operative laparoscopy.

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Abstract

STUDY OBJECTIVE: To externally validate the Endometriosis Fertility Index (EFI) and to assess cumulative spontaneous pregnancy rates in women with moderate to severe endometriosis following fertility-enhancing minimally invasive surgery. DESIGN: Retrospective cohort study. SETTING: Tertiary-care center for infertility treatment. PARTICIPANTS: Women diagnosed with r-ASRM Stage III or IV endometriosis following fertility-sparing surgery between June 2013 and July 2023, and who desired for fertility. INTERVENTION: Minimally invasive laparoscopy. MEASUREMENTS AND MAIN RESULTS: The follow-up rate was 76.3 %, with a median duration of 15 months [Range (1-130 months)]. The mean age of women was 28.5 ± 3.8 years. Women with low EFI scores (0-3) had lower cumulative spontaneous pregnancy rates (11.4 % at six months, 17 % at three years) compared to those with higher EFI scores (7-8), who had significantly higher rates (35 % at six months, 84.5 % after three years) (P < 0.001). A similar trend was observed for overall pregnancy rates. Factors negatively correlated with spontaneous pregnancy included lower least function scores (P < 0.001), increasing maternal age (P = 0.003), rASRM scores of 16-40 vs. ≥ 71 (P < 0.001), lower antral follicle count (P = 0.02), and increasing paternal age (P < 0.001). Cystectomy (P = 0.001) was positively associated with spontaneous pregnancy post-surgery. Among the 518 women identified with moderate and severe endometriosis, 395 were followed up, out of which 370 attempted spontaneous conception for at least six months, resulting in a pregnancy rate of 37.3 % (138/370). CONCLUSION: The current study demonstrated that EFI scores correlate with pregnancy rates, validating the scoring system in a South Asian population. Additionally, clinical factors such as low antral follicle count, and advanced paternal age may be considered to make informed clinical decisions post-surgery for women with advanced endometriosis who wish to conceive.

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Condition tags

endometriosis

MeSH descriptors

Endometriosis Endometriosis Endometriosis Endometriosis Endometriosis Endometriosis Endometriosis Endometriosis Endometriosis Endometriosis Endometriosis Endometriosis Endometriosis Endometriosis Endometriosis Endometriosis Endometriosis Endometriosis Endometriosis Endometriosis

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Papers in the corpus that this work cites (lower rings, blue) and that cite this one (upper rings, green). Dot size scales with the paper's in-corpus citation count — bigger dot = more influential within the endo/adeno field. Click a dot to open that paper. Outer rings show 2-hop neighbours — papers reached through the immediate citers/citees. [ collapse to 1-hop ]

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