Analysis of the metabolic profile and comorbidities in women with endometriosis before and after surgical treatment

Claruza Braga Holanda Lavor, Antônio Brazil Viana Júnior, Francisco das Chagas Medeiros
In: Journal of Health & Biological Sciences · 2024 · vol. 12(1) , pp. 1–5 · doi:10.12662/2317-3076jhbs.v12i1.4949.p1-5.2024 · W4390730250
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Surgical treatment for deep endometriosis in women was associated with significant improvements in lipid profiles and fasting glycemia six months post-procedure.

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This prospective observational study evaluated how surgical treatment affects metabolic profiles in 30 women with deep endometriosis, assessed at baseline during preoperative testing and again six months after videolaparoscopic surgery in Brazil (Oct 2020–Dec 2021). Across follow-up, average levels of total cholesterol, LDL cholesterol, triglycerides, and fasting glycemia were lower after surgery, with statistically significant differences reported for all measured parameters (p < 0.001). The paper’s main limitation is that it uses a small sample and only provides six-month follow-up, so durability of changes is uncertain. This paper is centrally about endometriosis — it examines metabolic profile changes after videolaparoscopic surgery for deep endometriosis.

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Abstract

Aim: this study aimed to evaluate the effects of surgical treatment for endometriosis on the metabolic profile of women diagnosed with deep endometriosis. Methods: we conducted a prospective observational study with a sample of 30 women in the menacme diagnosed with deep endometriosis who underwent videolaparoscopic surgery in a reference center in Brazil between October 2020 and December 2021. A total of 30 women performed clinical and laboratory tests regarding their metabolic profile on two occasions, during preoperative tests and six months after video-laparoscopy. Results: patients had lower average levels of Total Cholesterol (TC), Low-Density Cholesterol (LDL-c), Triglycerides (TGC), and Fasting Glycemia (FG) after the surgical procedure. The average TC level was 8.2% lower after surgery, LDL-c was 12.8% lower, TGC was 10.9% lower, and FG was 7.3% lower. The results showed a statistically significant difference for all these parameters (p < 0.001). Conclusions: video-laparoscopy was associated with a favorable lipid profile compared to the preoperative lipid profile, with a significant improvement in the average levels of LDL-c, HDL-c, TC, TGC, and FG. Long-term follow-up studies are needed to determine whether surgical treatment for endometriosis can improve the metabolic parameters of women with endometriosis and favor a lower predisposition to atherogenesis.
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Analysis of the metabolic profile and comorbidities in women with endometriosis before and after surgical treatment DOI: https://doi.org/10.12662/2317-3076jhbs.v12i1.4949.p1-5.2024Palavras-chave: endometriosis, videolaparoscopy, dyslipidemia, inflammatory response, pelvic painResumo Aim: this study aimed to evaluate the effects of surgical treatment for endometriosis on the metabolic profile of women diagnosed with deep endometriosis. Methods: we conducted a prospective observational study with a sample of 30 women in the menacme diagnosed with deep endometriosis who underwent videolaparoscopic surgery in a reference center in Brazil between October 2020 and December 2021. A total of 30 women performed clinical and laboratory tests regarding their metabolic profile on two occasions, during preoperative tests and six months after video-laparoscopy. Results: patients had lower average levels of Total Cholesterol (TC), Low-Density Cholesterol (LDL-c), Triglycerides (TGC), and Fasting Glycemia (FG) after the surgical procedure. The average TC level was 8.2% lower after surgery, LDL-c was 12.8% lower, TGC was 10.9% lower, and FG was 7.3% lower. The results showed a statistically significant difference for all these parameters (p < 0.001). Conclusions: video-laparoscopy was associated with a favorable lipid profile compared to the preoperative lipid profile, with a significant improvement in the average levels of LDL-c, HDL-c, TC, TGC, and FG. Long-term follow-up studies are needed to determine whether surgical treatment for endometriosis can improve the metabolic parameters of women with endometriosis and favor a lower predisposition to atherogenesis. Downloads Downloads Publicado Como Citar Edição Seção Licença Copyright (c) 2024 Claruza Braga Holanda Lavor, Antonio Brazil Viana Júnior, Francisco das Chagas Medeiros Este trabalho está licenciado sob uma licença Creative Commons Attribution-NonCommercial 4.0 International License.

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endometriosis

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