Obesity does not alter endometrial gene expression in women with endometriosis

Sarah J. Holdsworth‐Carson, Sarah J Holdsworth-Carson, Jessica Chung, Clare Sloggett, Sally Mortlock, Jenny N. Fung, Montgomery GW, Grant W. Montgomery, Uri P. Dior, Martin Healey, Healey M, Peter A. W. Rogers, Peter Aw Rogers, Jane E. Girling
Reproductive BioMedicine Online · 2020 · vol. 41(1) , pp. 113–118 · doi:10.1016/j.rbmo.2020.03.015 · PMID:32456970 · W3022975396
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This study investigated the relationship between obesity and endometrial gene expression in women with endometriosis, finding no significant alterations in gene expression due to obesity.

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Abstract

Research questionDoes obesity affect endometrial gene expression in women with endometriosis, specifically women with stage I disease?DesignDifferential gene expression analysis was conducted on endometrium from women with and without endometriosis (n = 169). Women were diagnosed after surgical visualization and staged according to the revised American Society for Reproductive Medicine (stage I-IV). Women were grouped by body mass index (BMI) (kg/m2) as underweight, normal, pre-obese or obese. After accounting for menstrual cycle stage, endometrial gene expression was analysed by BMI (continuous and grouped) in women with endometriosis, and in non-endometriosis controls.ResultsNo significant interaction effect was found between BMI and endometriosis status on endometrial gene expression. We have previously reported that obese women with endometriosis have a reduced incidence of stage I disease; however, stratifying our analysis into stage I endometriosis versus combined II, III and IV endometriosis failed to reveal any differentially expressed endometrial genes between normal, pre-obese and obese patients.ConclusionsDespite obesity having deleterious effects on endometrial gene expression in other gynaecological pathologies, e.g. endometrial cancer and polycystic ovary syndrome, our results do not support an association between BMI and altered endometrial gene expression in women with or without endometriosis.

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Condition tags

endometriosis

MeSH descriptors

Endometriosis Endometrium Gene Expression Gene Expression Regulation Obesity Adolescent Adult Body Mass Index Endometriosis Endometriosis Endometriosis Endometrium Female Humans Middle Aged Obesity Obesity Obesity Young Adult

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