Effects of danazol on endometrial DNA synthesis in rats

Satoe Suzuki; S Suzuki; Shinobu Sakamoto; S. Sakamoto; Hideki Kudo; H Kudo; Shuji Sassa; S Sassa; Y Sugiura; Yoshie Sugiura; K Kuwa; Katsuhiko Kuwa; Noriyuki Kasahara; N Kasahara; Takao Mori; T Mori; Hiroshi Nagasawa; H. Nagasawa

doi:10.1016/0039-128x(93)90034-k

Effects of danazol on endometrial DNA synthesis in rats

Satoe Suzuki, S Suzuki, Shinobu Sakamoto, S. Sakamoto, Hideki Kudo, H Kudo, Shuji Sassa, S Sassa, Y Sugiura, Yoshie Sugiura, K Kuwa, Katsuhiko Kuwa, Noriyuki Kasahara, N Kasahara, Takao Mori, T Mori, Hiroshi Nagasawa, H. Nagasawa

Steroids · 1993 · vol. 58(11) , pp. 551–553 · doi:10.1016/0039-128x(93)90034-k · PMID:8273119 · W2073088147

Lab / animal OA: closed CC0 ⤵ 1 in-corpus citation

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Danazol administration in rats inhibited endometrial DNA synthesis, suggesting a direct effect on uterine cell proliferation.

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Abstract

The suppressive effects of Danazol, an isoxazol derivative of the synthetic steroid 17 alpha-ethinyltestosterone, on endometrial DNA synthesis were investigated in rats by immunohistochemistry with bromodeoxyuridine (BrdU) and DNA-synthesizing enzyme assays. Rats treated with Danazol for 14 days at 17-19 weeks of age showed a decrease of plasma gonadotropins associated with ovarian hypofunction, persistent diestrus, and a smaller number of corpora lutea in ovary, resulting in no BrdU-immunoreactive (S-phase) cells in endometrial epithelium and lower activity of thymidine kinase in the uterus compared with control.

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MeSH descriptors

Danazol DNA Endometrium Adrenal Glands Adrenal Glands Animals Bromodeoxyuridine Bromodeoxyuridine Danazol DNA Endometrium Endometrium Estrus Estrus Female Immunohistochemistry Luteinizing Hormone Luteinizing Hormone Organ Size Organ Size

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References (20)

A new therapy for pelvic endometriosis and uterine adenomyosis: local effect of vaginal and intrauterine danazol application via openalex
ANTIGONADOTROPIN (DANAZOL) IN THE TREATMENT OF ENDOMETRIOSIS via openalex
Antigonadotropin (danazol) in the treatment of endometriosis. Evaluation of posttreatment fertility and three-year follow-up data via openalex
Danazol binds to progesterone receptors and inhibits the growth of human endometrial cancer cells in vitro via openalex
Danazol effects on gonadotropin basal levels and pituitary responsiveness to LH-RH in immature male rats via openalex
Danazol inhibits steroidogenesis in the rat testis in vitro via openalex
Effects of danazol on DNA synthesis in rat prostate via openalex
Effects of danazol on DNA synthesis in submaxillary glands of male rats via openalex
Pituitary gonadotropin inhibitory activity of danazol via openalex
Pituitary gonadotropin responsiveness with danazol via openalex
Suppression of the development of uterine adenomyosis by danazol treatment in mice via openalex
The effect of danazol in the treatment of chronic cystic mastitis via openalex
doi:10.1126/science.7123245 via openalex
doi:10.1016/0022-1759(86)90438-2 via openalex
doi:10.1093/carcin/8.3.405 via openalex
doi:10.1089/thy.1991.1.347 via openalex
doi:10.1021/bi00777a014 via openalex
doi:10.1016/0002-9378(81)90611-6 via openalex
doi:10.1016/s0015-0282(16)44350-5 via openalex
doi:10.1016/s0021-9258(19)45559-2 via openalex

Cited by (1)

Danazol: prolonged suppression of gonadotropins after subcutaneous administration in the castrate male rat 1994

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[1] A new therapy for pelvic endometriosis and uterine adenomyosis: local effect of vaginal and intrauterine danazol application via openalex

[2] ANTIGONADOTROPIN (DANAZOL) IN THE TREATMENT OF ENDOMETRIOSIS via openalex

[3] Antigonadotropin (danazol) in the treatment of endometriosis. Evaluation of posttreatment fertility and three-year follow-up data via openalex

[4] Danazol binds to progesterone receptors and inhibits the growth of human endometrial cancer cells in vitro via openalex

[5] Danazol effects on gonadotropin basal levels and pituitary responsiveness to LH-RH in immature male rats via openalex

[6] Danazol inhibits steroidogenesis in the rat testis in vitro via openalex

[7] Effects of danazol on DNA synthesis in rat prostate via openalex

[8] Effects of danazol on DNA synthesis in submaxillary glands of male rats via openalex

[9] Pituitary gonadotropin inhibitory activity of danazol via openalex

[10] Pituitary gonadotropin responsiveness with danazol via openalex

[11] Suppression of the development of uterine adenomyosis by danazol treatment in mice via openalex

[12] The effect of danazol in the treatment of chronic cystic mastitis via openalex

[13] doi:10.1126/science.7123245 via openalex

[14] doi:10.1016/0022-1759(86)90438-2 via openalex

[15] doi:10.1093/carcin/8.3.405 via openalex

[16] doi:10.1089/thy.1991.1.347 via openalex

[17] doi:10.1021/bi00777a014 via openalex

[18] doi:10.1016/0002-9378(81)90611-6 via openalex

[19] doi:10.1016/s0015-0282(16)44350-5 via openalex

[20] doi:10.1016/s0021-9258(19)45559-2 via openalex