Effects of danazol on DNA synthesis in submaxillary glands of male rats.
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Danazol administration reduced luteinizing hormone, testosterone, and S-phase cells in male rat submaxillary glands, indicating antiandrogenic or antigonadotrophic activity.
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Abstract
Danazol is an isoxazol derivative of the synthetic steroid, 17 alpha-ethinyltestosterone (ethisterone). Intragastric administration of danazol (10 mg/100 g body weight) markedly reduced plasma levels of luteinizing hormone and testosterone, and the number of S-phase cells labelled with bromodeoxyuridine (BrdU) in the submaxillary glands which were androgen-dependent in adult male rats. These results demonstrated that danazol might show a potency as antiandrogenic and/or antigonadotrophic agent.
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- last seen: 2026-05-10T10:49:32.617928+00:00
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