Chronic pelvic pain treated with gabapentin and amitriptyline: A randomized controlled pilot study

Sabine Sator, Gisela Scharbert, Hans G. Kress, Nathalie Frickey, Alexandra Ellend, Andreas Gleiß, Sibylle A. Kozek‐Langenecker
In: Wiener klinische Wochenschrift · 2005 · vol. 117(21-22) , pp. 761–768 · doi:10.1007/s00508-005-0464-2 · PMID:16416358 · W1582528366
article OA: closed CC0 ⤵ 62 in-corpus citations
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⚙ AI-generated summary by claude@2026-06+body, 2026-06-06 ⓘ

This pilot study found that gabapentin alone or combined with amitriptyline provided better pain relief and fewer side effects than amitriptyline monotherapy in women with chronic pelvic pain over two years.

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⚙ AI-generated deep summary by claude@2026-06, 2026-06-06 ⓘ

This open-label, prospective randomized pilot trial compared gabapentin, amitriptyline, and their combination in 56 women with chronic pelvic pain who had persistent pain (VAS ≥5) despite nonopioid analgesia with metamizol plus weak opioids, with follow-up for 2 years. Doses were titrated up to 3600 mg/day for gabapentin and 150 mg/day for amitriptyline, and pain intensity (VAS) and side effects were assessed before treatment and at 1, 3, 6, 12, and 24 months. All groups experienced significant pain relief, but pain reduction was significantly better with gabapentin alone or combined with amitriptyline than with amitriptyline monotherapy at 6, 12, and 24 months, and side effects were lower in the gabapentin group. The paper does not explicitly discuss endometriosis or adenomyosis; it was included in the corpus via a keyword match in the upstream search index.

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