Is gabapentin effective and safe in the treatment of chronic pelvic pain in women: a systematic review and meta-analysis

Yuewen He, Xuhui Zhuang, Wuhua Ma
In: International Urogynecology Journal · 2022 · vol. 33(5) , pp. 1071–1081 · doi:10.1007/s00192-021-05017-0 · PMID:35013759 · W4205209767
review OA: closed CC0 ⤵ 1 in-corpus citation
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⚙ AI-generated summary by claude@2026-06+body, 2026-06-08 ⓘ

This meta-analysis found gabapentin reduced average pain scores at 3 and 6 months in women with chronic pelvic pain, but not from baseline, and increased side effects compared to placebo.

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⚙ AI-generated deep summary by claude@2026-06, 2026-06-08 ⓘ

This systematic review and meta-analysis evaluated the efficacy and safety of gabapentin versus placebo for reducing pain in women with chronic pelvic pain, pooling data from randomized controlled trials identified via database searches (PubMed, Embase, Web of Science, Scopus, Cochrane, and Clinicalkey). Four RCTs (425 patients) were included, and gabapentin was associated with significantly lower average pain scores at 3 and 6 months compared with placebo, but there was no statistically significant difference between groups in pain score reduction from baseline. The incidence of side effects was significantly higher with gabapentin than with placebo. The review’s limitation is that only four RCTs were available for pooling, despite using standard risk-of-bias assessment and meta-analytic methods. Relevance to endometriosis: chronic pelvic pain is a key clinical presentation in which endometriosis is often implicated, though this meta-analysis is not specifically focused on endometriosis or adenomyosis.

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Condition tags

chronic_pelvic_pain

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SciLite annotations

chemicals 7
gabapentin gabapentin gabapentin gabapentin gabapentin gabapentin gabapentin
organisms 4
noordeloos 2009062 noordeloos 2009062 noordeloos 2009062 noordeloos 2009062

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